POR and CYP2D6

Number of citations of the paper that reports this interaction (PMID 15680923)
10

Data Source:
BioGRID (pull down, pull down)

		POR	CYP2D6
Gene Name		P450 (cytochrome) oxidoreductase	cytochrome P450, family 2, subfamily D, polypeptide 6
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane
	Molecular Function	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Iron Ion Binding Protein Binding Nitric Oxide Dioxygenase Activity Electron Carrier Activity FMN Binding Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding	Monooxygenase Activity Iron Ion Binding Drug Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity
	Biological Process	Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Response To Nutrient Carnitine Metabolic Process Flavonoid Metabolic Process Internal Peptidyl-lysine Acetylation Fatty Acid Oxidation Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Monooxygenase Activity Response To Drug Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Oxidation-reduction Process Negative Regulation Of Lipase Activity Demethylation Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Steroid Hormone Biosynthetic Process Cellular Organofluorine Metabolic Process	Xenobiotic Metabolic Process Steroid Metabolic Process Coumarin Metabolic Process Alkaloid Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Small Molecule Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Binding Oxidation-reduction Process Oxidative Demethylation Negative Regulation Of Cellular Organofluorine Metabolic Process
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Miscellaneous substrates Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Fatty acids Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs		Flavin-Adenine Dinucleotide Riboflavin Monophosphate 2\'-Monophosphoadenosine 5\'-Diphosphoribose	Paliperidone
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 FANCC HMOX1 RABEPK STAT1 XRCC6	3 interactors: CYB5A CYP2C9 POR
Entrez ID		5447	1565
HPRD ID		00485	00487
Ensembl ID		ENSG00000127948	ENSG00000100197
Uniprot IDs		E7EVY7 F5H468 P16435	C1ID52 P10635 Q5Y7H2
PDB IDs		1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT	2F9Q 3QM4 3TBG 3TDA
Enriched GO Terms of Interacting Partners?		Monoterpenoid Metabolic Process Exogenous Drug Catabolic Process Drug Catabolic Process Drug Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Epoxygenase P450 Pathway Steroid Metabolic Process Arachidonic Acid Metabolic Process Response To Drug Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Isoprenoid Metabolic Process Oxidative Demethylation Oxidation-reduction Process Omega-hydroxylase P450 Pathway Fatty Acid Metabolic Process Alkaloid Metabolic Process Carboxylic Acid Metabolic Process Demethylation Small Molecule Metabolic Process Organic Acid Metabolic Process Response To Inorganic Substance Lipid Metabolic Process Monocarboxylic Acid Metabolic Process Cellular Lipid Metabolic Process Alkaloid Catabolic Process Catabolic Process Response To Reactive Oxygen Species Heterocycle Metabolic Process Response To Cadmium Ion Response To Stimulus Coumarin Metabolic Process Cellular Response To Stimulus Dibenzo-p-dioxin Metabolic Process Cellular Response To Cadmium Ion Response To Oxidative Stress Steroid Catabolic Process Cellular Metabolic Process Androgen Metabolic Process Porphyrin-containing Compound Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cellular Organofluorine Metabolic Process Negative Regulation Of Macrophage Fusion Oxidative Deethylation Response To Acetate Toxin Biosynthetic Process Response To Lipopolysaccharide	Demethylation Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cellular Organofluorine Metabolic Process Nitric Oxide Catabolic Process Nitrate Catabolic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Oxidation-reduction Process Nitrate Metabolic Process Fatty Acid Metabolic Process Monoterpenoid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Small Molecule Metabolic Process Omega-hydroxylase P450 Pathway Positive Regulation Of Hormone Biosynthetic Process Response To Drug L-ascorbic Acid Metabolic Process Oxidative Demethylation Urea Metabolic Process Monocarboxylic Acid Metabolic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Epoxygenase P450 Pathway Amino-acid Betaine Metabolic Process Negative Regulation Of Lipase Activity Regulation Of Cholesterol Biosynthetic Process Exogenous Drug Catabolic Process Response To Follicle-stimulating Hormone Drug Catabolic Process Cellular Response To Gonadotropin Stimulus Flavonoid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Nitric Oxide Metabolic Process Regulation Of Cholesterol Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Chondrocyte Differentiation Regulation Of Hormone Metabolic Process Drug Metabolic Process Cellular Lipid Metabolic Process Positive Regulation Of Oxidoreductase Activity Response To Gonadotropin Positive Regulation Of Cartilage Development Positive Regulation Of Smoothened Signaling Pathway Response To Cadmium Ion Positive Regulation Of Lipid Biosynthetic Process Arachidonic Acid Metabolic Process
Tagcloud ?		5c 7h adjuvant aluminiumphosphate bactericidal class deoxycholate donors engineered extraction final formulated genetically meningococcal mixed omps omv outer p1 pora prepared represent safe serogroup served strains vaccine vaccines vesicles	ab associations bcc bccs comprised cytochrome em genotypes glutathione gstm1 gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv
Tagcloud (Difference) ?		5c 7h adjuvant aluminiumphosphate bactericidal class deoxycholate donors engineered extraction final formulated genetically meningococcal mixed omps omv outer p1 pora prepared represent safe serogroup served strains vaccine vaccines vesicles	ab associations bcc bccs comprised cytochrome em genotypes glutathione gstm1 gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv
Tagcloud (Intersection) ?