CYB5A and CYP17A1

Number of citations of the paper that reports this interaction (PubMedID 9601054)
25

Data Source:
HPRD (in vitro)

		CYB5A	CYP17A1
Description		cytochrome b5 type A	cytochrome P450 family 17 subfamily A member 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Axon Neuronal Cell Body
	Molecular Function	Protein Binding Enzyme Binding Heme Binding Metal Ion Binding	Monooxygenase Activity Steroid 17-alpha-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Oxygen Binding Heme Binding Metal Ion Binding
	Biological Process		Lipid Metabolic Process Steroid Biosynthetic Process Androgen Biosynthetic Process Glucocorticoid Biosynthetic Process Sex Differentiation Steroid Metabolic Process Cortisol Biosynthetic Process Hormone Metabolic Process Hormone Biosynthetic Process Progesterone Metabolic Process Olefinic Compound Metabolic Process
Pathways		Vitamin C (ascorbate) metabolism	Androgen biosynthesis Glucocorticoid biosynthesis Defective CYP17A1 causes AH5
Drugs		Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate	NADH Progesterone Spironolactone Ketoconazole Levoketoconazole Abiraterone Cannabidiol Medical Cannabis Nabiximols
Diseases		Methemoglobinemia	Congenital adrenal hyperplasia (CAH) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Blood protein levels ( 30072576)	Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758) Blood pressure ( 21572416 21909110 24001895) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 26965516) Coronary artery disease ( 24262325 26343387 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 28739976 27618452 25249183 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Hip circumference ( 25673412) Hypertension ( 25249183 31879980 30487518) Mean arterial pressure ( 26390057 27618448 30487518) Microalbuminuria ( 26631737) Myocardial infarction ( 33532862 26343387) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Pulse pressure ( 30487518 27841878 28739976) Schizophrenia ( 29483656 25056061 23974872) Sodium levels ( 29403010) Systolic blood pressure ( 30487518 28739976 27618447 28135244 27841878 27736895 27618452 19430479 26390057 25249183 21909115 19430483) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Waist circumference ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	15 interacting genes: APC ATP5F1E BARX1 CDO1 CHEK2 CYB5A ERBB2 FZR1 HSP90AB1 IGF1R POR PTPRJ RPAIN STK11 TIGD7
Entrez ID		1528	1586
HPRD ID		08941	01944
Ensembl ID		ENSG00000166347	ENSG00000148795
Uniprot IDs		A0A384ME44 P00167	P05093 Q1HB44
PDB IDs		2I96	3RUK 3SWZ 4NKV 4NKW 4NKX 4NKY 4NKZ 5IRQ 5IRV 5UYS 6CHI 6CIR 6CIZ 6WR0 6WR1 6WW0 8FDA
Enriched GO Terms of Interacting Partners?		Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Iron Ion Binding Heme Binding Monooxygenase Activity Xenobiotic Metabolic Process Oxidoreductase Activity Endoplasmic Reticulum Membrane Lipid Metabolic Process Steroid Metabolic Process Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Small Molecule Metabolic Process Monocarboxylic Acid Metabolic Process Endoplasmic Reticulum Fatty Acid Metabolic Process Epoxygenase P450 Pathway Unsaturated Fatty Acid Metabolic Process Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Secondary Metabolic Process Monoterpenoid Metabolic Process Small Molecule Biosynthetic Process Xenobiotic Catabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Terpenoid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Demethylation Isoprenoid Metabolic Process Fatty Acid Biosynthetic Process Coumarin Metabolic Process Carboxylic Acid Biosynthetic Process Steroid Hydroxylase Activity Toxin Metabolic Process Alcohol Metabolic Process Lipid Biosynthetic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Hormone Metabolic Process Oxygen Binding Lipid Hydroxylation Enzyme Binding Estrogen Metabolic Process Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Oxidative Demethylation Aflatoxin Metabolic Process Alkaloid Metabolic Process	Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity Protein Kinase Regulator Activity Ruffle Membrane Regulation Of Kinase Activity Regulation Of Catalytic Activity Gamma-catenin Binding Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Protein Autophosphorylation Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Cold-induced Thermogenesis Regulation Of Protein Catabolic Process Regulation Of Cell Population Proliferation Phosphorylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Protein Kinase Binding Regulation Of Cell Communication Negative Regulation Of Mitotic Cell Cycle Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphate-containing Compound Metabolic Process Response To Azide Cysteine Dioxygenase Activity Oligodendrocyte Differentiation Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Carbohydrate Homeostasis Glucose Homeostasis Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Microtubule-based Movement Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Phosphorus Metabolic Process
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