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CYB5A and CYP4A11
Number of citations of the paper that reports this interaction (PMID
10660572
)
24
Data Source:
BioGRID
(enzymatic study)
CYB5A
CYP4A11
Gene Name
cytochrome b5 type A (microsomal)
cytochrome P450, family 4, subfamily A, polypeptide 11
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Mitochondrial Outer Membrane
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Extracellular Vesicular Exosome
Cytoplasm
Endoplasmic Reticulum Membrane
Apical Plasma Membrane
Intracellular Membrane-bounded Organelle
Extracellular Vesicular Exosome
Molecular Function
Aldo-keto Reductase (NADP) Activity
Cytochrome-c Oxidase Activity
Enzyme Binding
Heme Binding
Metal Ion Binding
Iron Ion Binding
Arachidonic Acid Epoxygenase Activity
Alkane 1-monooxygenase Activity
Heme Binding
Leukotriene-B4 20-monooxygenase Activity
Arachidonic Acid Omega-hydroxylase Activity
Biological Process
Vitamin Metabolic Process
Water-soluble Vitamin Metabolic Process
L-ascorbic Acid Metabolic Process
Small Molecule Metabolic Process
Response To Cadmium Ion
Oxidation-reduction Process
Hydrogen Ion Transmembrane Transport
Long-chain Fatty Acid Metabolic Process
Renal Water Homeostasis
Pressure Natriuresis
Fatty Acid Metabolic Process
Leukotriene Metabolic Process
Xenobiotic Metabolic Process
Arachidonic Acid Metabolic Process
Epoxygenase P450 Pathway
Positive Regulation Of Icosanoid Secretion
Leukotriene B4 Catabolic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Sodium Ion Homeostasis
Oxidation-reduction Process
Omega-hydroxylase P450 Pathway
Pathways
Metabolism of vitamins and cofactors
Defective CD320 causes methylmalonic aciduria
Defective GIF causes intrinsic factor deficiency
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
Defective HLCS causes multiple carboxylase deficiency
Defective MMAB causes methylmalonic aciduria type cblB
Defective BTD causes biotidinase deficiency
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Vitamin C (ascorbate) metabolism
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defective MMAA causes methylmalonic aciduria type cblA
Defective CUBN causes hereditary megaloblastic anemia 1
Defective AMN causes hereditary megaloblastic anemia 1
Defective MUT causes methylmalonic aciduria mut type
Metabolism of water-soluble vitamins and cofactors
Defects in biotin (Btn) metabolism
Defective TCN2 causes hereditary megaloblastic anemia
Defects in cobalamin (B12) metabolism
Defects in vitamin and cofactor metabolism
PPARA activates gene expression
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Metabolism of lipids and lipoproteins
Metabolic disorders of biological oxidation enzymes
Phase 1 - Functionalization of compounds
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Arachidonic acid metabolism
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
Biological oxidations
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Defective FMO3 causes Trimethylaminuria (TMAU)
Fatty acid, triacylglycerol, and ketone body metabolism
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Miscellaneous substrates
Defective CYP1B1 causes Glaucoma
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Fatty acids
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Heme
Dimethyl Propionate Ester Heme
NADH
Diseases
GWAS
Protein-Protein Interactions
15 interactors:
CYB5R3
CYCS
CYP17A1
CYP1A1
CYP1A2
CYP2A6
CYP2D6
CYP2E1
CYP2W1
CYP3A4
CYP4A11
CYP4F2
POR
SCD
UGT1A4
2 interactors:
CYB5A
PIK3R1
Entrez ID
1528
1579
HPRD ID
08941
03201
Ensembl ID
ENSG00000166347
ENSG00000187048
Uniprot IDs
P00167
Q02928
PDB IDs
2I96
Enriched GO Terms of Interacting Partners
?
Xenobiotic Metabolic Process
Cellular Response To Xenobiotic Stimulus
Response To Xenobiotic Stimulus
Drug Metabolic Process
Epoxygenase P450 Pathway
Oxidation-reduction Process
Exogenous Drug Catabolic Process
Organic Acid Metabolic Process
Small Molecule Metabolic Process
Drug Catabolic Process
Arachidonic Acid Metabolic Process
Carboxylic Acid Metabolic Process
Fatty Acid Metabolic Process
Icosanoid Metabolic Process
Monocarboxylic Acid Metabolic Process
Unsaturated Fatty Acid Metabolic Process
Lipid Metabolic Process
Long-chain Fatty Acid Metabolic Process
Steroid Metabolic Process
Monoterpenoid Metabolic Process
Response To Drug
Omega-hydroxylase P450 Pathway
Catabolic Process
Cellular Lipid Metabolic Process
Demethylation
Coumarin Metabolic Process
Isoprenoid Metabolic Process
Dibenzo-p-dioxin Metabolic Process
Alkaloid Metabolic Process
Toxin Metabolic Process
Oxidative Demethylation
Flavonoid Metabolic Process
Vitamin Metabolic Process
Alkaloid Catabolic Process
Pressure Natriuresis
Leukotriene B4 Catabolic Process
Cellular Metabolic Process
Cellular Response To Stimulus
Porphyrin-containing Compound Metabolic Process
Positive Regulation Of Steroid Hormone Biosynthetic Process
Long-chain Fatty Acid Catabolic Process
Response To Herbicide
Heterocycle Metabolic Process
Hydrogen Peroxide Biosynthetic Process
Lipid Catabolic Process
Cellular Ketone Metabolic Process
Positive Regulation Of Hormone Biosynthetic Process
Tetrapyrrole Metabolic Process
Lipid Biosynthetic Process
Vitamin D Metabolic Process
NFAT Protein Import Into Nucleus
Transcription Factor Import Into Nucleus
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Tagcloud
?
administering
anxa1
c4bpalpha
cox2
cpla2alpha
crip1
ctsl1
endorses
eva1
gstp1
hgd
il6st
interferes
levonorgestrel
lng
loc90133
maoa
mifepristone
ovulatory
paep
receptive
receptivity
s100a4
sat1
serpinb9
slc25a29
slc39a14
tgm2
unproven
Tagcloud (Difference)
?
administering
anxa1
c4bpalpha
cox2
cpla2alpha
crip1
ctsl1
endorses
eva1
gstp1
hgd
il6st
interferes
levonorgestrel
lng
loc90133
maoa
mifepristone
ovulatory
paep
receptive
receptivity
s100a4
sat1
serpinb9
slc25a29
slc39a14
tgm2
unproven
Tagcloud (Intersection)
?