CYB5A and UGT1A4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CYB5A	UGT1A4
Gene Name		cytochrome b5 type A (microsomal)	UDP glucuronosyltransferase 1 family, polypeptide A4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Aldo-keto Reductase (NADP) Activity Cytochrome-c Oxidase Activity Enzyme Binding Heme Binding Metal Ion Binding	Retinoic Acid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process L-ascorbic Acid Metabolic Process Small Molecule Metabolic Process Response To Cadmium Ion Oxidation-reduction Process Hydrogen Ion Transmembrane Transport	Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Flavonoid Biosynthetic Process Cellular Response To Hormone Stimulus Heme Catabolic Process Small Molecule Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Heme degradation Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Metabolism of porphyrins Glucuronidation Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Heme Dimethyl Propionate Ester Heme
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 CYP4F2 POR SCD UGT1A4	1 interactors: CYB5A
Entrez ID		1528	54657
HPRD ID		08941	08402
Ensembl ID		ENSG00000166347	ENSG00000244474
Uniprot IDs		P00167	P22310
PDB IDs		2I96
Enriched GO Terms of Interacting Partners?		Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Drug Metabolic Process Epoxygenase P450 Pathway Oxidation-reduction Process Exogenous Drug Catabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Drug Catabolic Process Arachidonic Acid Metabolic Process Carboxylic Acid Metabolic Process Fatty Acid Metabolic Process Icosanoid Metabolic Process Monocarboxylic Acid Metabolic Process Unsaturated Fatty Acid Metabolic Process Lipid Metabolic Process Long-chain Fatty Acid Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Response To Drug Omega-hydroxylase P450 Pathway Catabolic Process Cellular Lipid Metabolic Process Demethylation Coumarin Metabolic Process Isoprenoid Metabolic Process Dibenzo-p-dioxin Metabolic Process Alkaloid Metabolic Process Toxin Metabolic Process Oxidative Demethylation Flavonoid Metabolic Process Vitamin Metabolic Process Alkaloid Catabolic Process Pressure Natriuresis Leukotriene B4 Catabolic Process Cellular Metabolic Process Cellular Response To Stimulus Porphyrin-containing Compound Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Long-chain Fatty Acid Catabolic Process Response To Herbicide Heterocycle Metabolic Process Hydrogen Peroxide Biosynthetic Process Lipid Catabolic Process Cellular Ketone Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Tetrapyrrole Metabolic Process Lipid Biosynthetic Process Vitamin D Metabolic Process	L-ascorbic Acid Metabolic Process Response To Cadmium Ion Water-soluble Vitamin Metabolic Process Vitamin Metabolic Process Hydrogen Ion Transmembrane Transport Proton Transport Monosaccharide Metabolic Process
Tagcloud ?		administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 serpinb9 slc25a29 slc39a14 tgm2 unproven	accounting car cnv discover esr1 fdr genotyped glucuronidation glucuronosyltransferases livers pharmacogenetic pxr quantified tagsnps tfs udp ugt2b ugt2b10 ugt2b15 ugt2b17 ugt2b4 ugt2b7 ugts
Tagcloud (Difference) ?		administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 serpinb9 slc25a29 slc39a14 tgm2 unproven	accounting car cnv discover esr1 fdr genotyped glucuronidation glucuronosyltransferases livers pharmacogenetic pxr quantified tagsnps tfs udp ugt2b ugt2b10 ugt2b15 ugt2b17 ugt2b4 ugt2b7 ugts
Tagcloud (Intersection) ?