POR and CYP2C19

Number of citations of the paper that reports this interaction (PubMedID 15680923)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		POR	CYP2C19
Description		cytochrome p450 oxidoreductase	cytochrome P450 family 2 subfamily C member 19
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Enzyme Activator Activity Nitric Oxide Dioxygenase NAD(P)H Activity Electron Transfer Activity FMN Binding Oxidoreductase Activity Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding	Monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Metal Ion Binding (R)-limonene 6-monooxygenase Activity Long-chain Fatty Acid Omega-1 Hydroxylase Activity
	Biological Process	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Nutrient Response To Xenobiotic Stimulus Carnitine Metabolic Process Response To Hormone Flavonoid Metabolic Process Fatty Acid Oxidation Electron Transport Chain Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Demethylation Cellular Response To Gonadotropin Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Response To Dexamethasone Positive Regulation Of Steroid Hormone Biosynthetic Process Organofluorine Metabolic Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Epoxygenase P450 Pathway Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Omega-hydroxylase P450 Pathway
Pathways		Cytochrome P450 - arranged by substrate type	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aspirin ADME
Drugs		Flavin adenine dinucleotide Flavin mononucleotide Nicotinamide adenine dinucleotide phosphate	Isoniazid Benzbromarone
Diseases		46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Coffee consumption ( 25288136 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708) High light scatter reticulocyte count ( 32888494) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Platelet count ( 32888494) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte count ( 32888494) Urinary albumin-to-creatinine ratio ( 31511532)	Acenocoumarol maintenance dosage ( 19578179) Appendicular lean mass ( 33097823) Clopidogrel active metabolite levels ( 28207573) Clozapine-to-N-desmethylclozapine metabolic ratio in schizophrenia ( 32555152) Diastolic blood pressure ( 27618448 27841878) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean arterial pressure ( 27618448) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 19706858 28207573) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 30578418 27841878) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose ( 23755828)
Interacting Genes		15 interacting genes: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 FANCC HMOX1 LINC01554 RABEPK STAT1 XRCC6	1 interacting genes: POR
Entrez ID		5447	1557
HPRD ID		00485	00486
Ensembl ID		ENSG00000127948	ENSG00000165841
Uniprot IDs		A0A9L9PY49 P16435	P33261
PDB IDs		1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT 5EMN 5FA6	4GQS
Enriched GO Terms of Interacting Partners?		Monoterpenoid Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Xenobiotic Catabolic Process Iron Ion Binding Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Epoxygenase P450 Pathway Steroid Hydroxylase Activity Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Xenobiotic Metabolic Process Oxidative Demethylation Steroid Metabolic Process Demethylation Long-chain Fatty Acid Biosynthetic Process Terpenoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Isoprenoid Metabolic Process Oxidoreductase Activity Caffeine Oxidase Activity Enzyme Binding Oxygen Binding Fatty Acid Metabolic Process Estrogen Metabolic Process Estrogen 2-hydroxylase Activity Endoplasmic Reticulum Membrane Alkaloid Metabolic Process Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Secondary Metabolic Process Fatty Acid Biosynthetic Process Monocarboxylic Acid Metabolic Process (S)-limonene 7-monooxygenase Activity (R)-limonene 6-monooxygenase Activity (S)-limonene 6-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Hormone Metabolic Process Endoplasmic Reticulum Coumarin Metabolic Process Alkaloid Catabolic Process Long-chain Fatty Acid Omega-1 Hydroxylase Activity Cholesterol Metabolic Process Carboxylic Acid Biosynthetic Process Small Molecule Biosynthetic Process	Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Positive Regulation Of Steroid Hormone Biosynthetic Process Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Demethylation Flavonoid Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Response To Follicle-stimulating Hormone FMN Binding Amino-acid Betaine Metabolic Process Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Chondrocyte Differentiation Cellular Response To Gonadotropin Stimulus Nitric Oxide Biosynthetic Process Regulation Of Hormone Biosynthetic Process Response To Gonadotropin Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Cartilage Development Regulation Of Hormone Metabolic Process Positive Regulation Of Steroid Biosynthetic Process NADP Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Steroid Metabolic Process Response To Dexamethasone Regulation Of Chondrocyte Differentiation Electron Transfer Activity Flavin Adenine Dinucleotide Binding Regulation Of Cartilage Development Enzyme Activator Activity Fatty Acid Oxidation Regulation Of Steroid Biosynthetic Process Lipid Oxidation Regulation Of Smoothened Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Electron Transport Chain Regulation Of Steroid Metabolic Process Xenobiotic Metabolic Process Response To Glucocorticoid Lipid Modification Intracellular Membrane-bounded Organelle Positive Regulation Of Lipid Metabolic Process
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