CYB5A and CYP2W1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CYB5A	CYP2W1
Description		cytochrome b5 type A	cytochrome P450 family 2 subfamily W member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Enzyme Binding Heme Binding Metal Ion Binding	Retinoic Acid Binding Monooxygenase Activity All-trans Retinal Binding Iron Ion Binding Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding All-trans-retinol Binding
	Biological Process		Organic Acid Metabolic Process Lipid Metabolic Process Phospholipid Metabolic Process Xenobiotic Metabolic Process Retinoic Acid Catabolic Process Aflatoxin Metabolic Process Cytochrome Metabolic Process
Pathways		Vitamin C (ascorbate) metabolism	Miscellaneous substrates Xenobiotics
Drugs		Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate
Diseases		Methemoglobinemia
GWAS		Blood protein levels ( 30072576)	Apolipoprotein A1 levels ( 32203549) Bronchopulmonary dysplasia ( 23897914) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	2 interacting genes: CYB5A ZBTB26
Entrez ID		1528	54905
HPRD ID		08941	07901
Ensembl ID		ENSG00000166347	ENSG00000073067
Uniprot IDs		A0A384ME44 P00167	Q8TAV3
PDB IDs		2I96
Enriched GO Terms of Interacting Partners?		Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Iron Ion Binding Heme Binding Monooxygenase Activity Xenobiotic Metabolic Process Oxidoreductase Activity Endoplasmic Reticulum Membrane Lipid Metabolic Process Steroid Metabolic Process Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Small Molecule Metabolic Process Monocarboxylic Acid Metabolic Process Endoplasmic Reticulum Fatty Acid Metabolic Process Epoxygenase P450 Pathway Unsaturated Fatty Acid Metabolic Process Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Secondary Metabolic Process Monoterpenoid Metabolic Process Small Molecule Biosynthetic Process Xenobiotic Catabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Terpenoid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Demethylation Isoprenoid Metabolic Process Fatty Acid Biosynthetic Process Coumarin Metabolic Process Carboxylic Acid Biosynthetic Process Steroid Hydroxylase Activity Toxin Metabolic Process Alcohol Metabolic Process Lipid Biosynthetic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Hormone Metabolic Process Oxygen Binding Lipid Hydroxylation Enzyme Binding Estrogen Metabolic Process Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Oxidative Demethylation Aflatoxin Metabolic Process Alkaloid Metabolic Process
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