POR and FANCC

Number of citations of the paper that reports this interaction (PubMedID 9787138)
0

Data Source:
BioGRID (affinity chromatography technology, biochemical, two hybrid)

		POR	FANCC
Description		cytochrome p450 oxidoreductase	FA complementation group C
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Enzyme Activator Activity Nitric Oxide Dioxygenase NAD(P)H Activity Electron Transfer Activity FMN Binding Oxidoreductase Activity Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding	Protein Binding
	Biological Process	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Nutrient Response To Xenobiotic Stimulus Carnitine Metabolic Process Response To Hormone Flavonoid Metabolic Process Fatty Acid Oxidation Electron Transport Chain Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Demethylation Cellular Response To Gonadotropin Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Response To Dexamethasone Positive Regulation Of Steroid Hormone Biosynthetic Process Organofluorine Metabolic Process	DNA Repair Nucleotide-excision Repair DNA Damage Response Cellular Response To Oxidative Stress Interstrand Cross-link Repair Protein-containing Complex Assembly
Pathways		Cytochrome P450 - arranged by substrate type	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes PKR-mediated signaling
Drugs		Flavin adenine dinucleotide Flavin mononucleotide Nicotinamide adenine dinucleotide phosphate
Diseases		46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)	Fanconi anemia
GWAS		Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Coffee consumption ( 25288136 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708) High light scatter reticulocyte count ( 32888494) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Platelet count ( 32888494) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte count ( 32888494) Urinary albumin-to-creatinine ratio ( 31511532)	Birth weight ( 31043758) Hematocrit ( 32888494) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 26284813)
Interacting Genes		15 interacting genes: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 FANCC HMOX1 LINC01554 RABEPK STAT1 XRCC6	54 interacting genes: APC AZIN1 BMPR1A BUB1 CAPN10 CCNA2 CCND1 CDK1 CTBP1 DLC1 DNAJB1 EGFR FANCA FANCD2 FANCE FANCF FANCG FBXW7 GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRAS KRT1 MEOX2 MLH3 MT-ATP6 MUTYH NRAS PDGFRL PIK3CA PMS2 POR PRDX3 PRPF31 PTPN12 PTPRJ RB1 RPL18 RPS3A SMAD4 SPTA1 SPTAN1 SRC STAT1 STMN1 STMN2 TCERG1 TGFBR2 USP14 ZBTB32
Entrez ID		5447	2176
HPRD ID		00485	01967
Ensembl ID		ENSG00000127948	ENSG00000158169
Uniprot IDs		A0A9L9PY49 P16435	A0A024R9N2 A0A087WW44 B4E3W2 Q00597
PDB IDs		1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT 5EMN 5FA6	7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		Monoterpenoid Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Xenobiotic Catabolic Process Iron Ion Binding Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Epoxygenase P450 Pathway Steroid Hydroxylase Activity Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Xenobiotic Metabolic Process Oxidative Demethylation Steroid Metabolic Process Demethylation Long-chain Fatty Acid Biosynthetic Process Terpenoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Isoprenoid Metabolic Process Oxidoreductase Activity Caffeine Oxidase Activity Enzyme Binding Oxygen Binding Fatty Acid Metabolic Process Estrogen Metabolic Process Estrogen 2-hydroxylase Activity Endoplasmic Reticulum Membrane Alkaloid Metabolic Process Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Secondary Metabolic Process Fatty Acid Biosynthetic Process Monocarboxylic Acid Metabolic Process (S)-limonene 7-monooxygenase Activity (R)-limonene 6-monooxygenase Activity (S)-limonene 6-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Hormone Metabolic Process Endoplasmic Reticulum Coumarin Metabolic Process Alkaloid Catabolic Process Long-chain Fatty Acid Omega-1 Hydroxylase Activity Cholesterol Metabolic Process Carboxylic Acid Biosynthetic Process Small Molecule Biosynthetic Process	Cytosol Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Supramolecular Fiber Organization Cellular Response To Stress Response To Stress Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Component Organization Negative Regulation Of Cytoskeleton Organization Response To Hormone Response To Growth Factor Fanconi Anaemia Nuclear Complex Cellular Response To Peptide Hormone Stimulus ATP-dependent Protein Folding Chaperone Cellular Response To Hormone Stimulus Interstrand Cross-link Repair Nucleoplasm Regulation Of Supramolecular Fiber Organization Response To Steroid Hormone Regulation Of Organelle Organization Negative Regulation Of Programmed Cell Death Cadherin Binding Positive Regulation Of Cell Population Proliferation Nucleus Focal Adhesion Protein Folding Chaperone Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Regulation Of Multicellular Organismal Process DNA Repair Regulation Of Immune System Process Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein-containing Complex Disassembly DNA Damage Response Intracellular Signal Transduction Response To Peptide Hormone Regulation Of Cytoskeleton Organization Response To Lipid G1/S Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Macromolecule Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cell Cycle Phase Transition Cell Cycle G1/S Phase Transition Response To Unfolded Protein Regulation Of Cellular Component Organization Regulation Of Cell Cycle Phase Transition Regulation Of Protein Depolymerization
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