CYB5A and CYP2A6

Number of citations of the paper that reports this interaction (PubMedID 15680923)
0

Data Source:
BioGRID (pull down)

		CYB5A	CYP2A6
Description		cytochrome b5 type A	cytochrome P450 family 2 subfamily A member 6
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GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Enzyme Binding Heme Binding Metal Ion Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Coumarin 7-hydroxylase Activity Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process		Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Coumarin Metabolic Process Epoxygenase P450 Pathway Xenobiotic Catabolic Process Coumarin Catabolic Process
Pathways		Vitamin C (ascorbate) metabolism	Xenobiotics CYP2E1 reactions
Drugs		Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate	Coumarin N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE 4,4'-DIPYRIDYL DISULFIDE
Diseases		Methemoglobinemia
GWAS		Blood protein levels ( 30072576)	Alanine aminotransferase levels ( 33547301) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33339817 29403010) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Cerebrospinal P-tau181p levels ( 26252872) Chronic obstructive pulmonary disease ( 22080838 28166215) Chronotype ( 30696823) Coffee consumption ( 31046077) Liver enzyme levels (alanine transaminase) ( 33972514) Local histogram emphysema pattern ( 25006744) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 33144568) Nicotine metabolite ratio in current smokers ( 27488534 26407342 28921760) Non-small cell lung cancer ( 31326317) Parental longevity (father's attained age) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum alkaline phosphatase levels ( 33339817 33547301) Smoking behavior ( 20418888 23049750 20418890) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 31089300 30679032 30617275) Smoking cessation ( 33082346) Smoking status (current vs mixed) ( 33082346) Squamous cell lung carcinoma ( 28604730) Urinary sodium excretion ( 31409800)
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	2 interacting genes: CYB5A POR
Entrez ID		1528	1548
HPRD ID		08941	00420
Ensembl ID		ENSG00000166347	ENSG00000255974
Uniprot IDs		A0A384ME44 P00167	P11509
PDB IDs		2I96	1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS 3T3Q 3T3R 4EJJ 4RUI
Enriched GO Terms of Interacting Partners?		Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Iron Ion Binding Heme Binding Monooxygenase Activity Xenobiotic Metabolic Process Oxidoreductase Activity Endoplasmic Reticulum Membrane Lipid Metabolic Process Steroid Metabolic Process Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Small Molecule Metabolic Process Monocarboxylic Acid Metabolic Process Endoplasmic Reticulum Fatty Acid Metabolic Process Epoxygenase P450 Pathway Unsaturated Fatty Acid Metabolic Process Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Secondary Metabolic Process Monoterpenoid Metabolic Process Small Molecule Biosynthetic Process Xenobiotic Catabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Terpenoid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Demethylation Isoprenoid Metabolic Process Fatty Acid Biosynthetic Process Coumarin Metabolic Process Carboxylic Acid Biosynthetic Process Steroid Hydroxylase Activity Toxin Metabolic Process Alcohol Metabolic Process Lipid Biosynthetic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Hormone Metabolic Process Oxygen Binding Lipid Hydroxylation Enzyme Binding Estrogen Metabolic Process Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Oxidative Demethylation Aflatoxin Metabolic Process Alkaloid Metabolic Process	Intracellular Membrane-bounded Organelle Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Enzyme Binding Positive Regulation Of Steroid Hormone Biosynthetic Process Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Positive Regulation Of Hormone Biosynthetic Process Demethylation Flavonoid Metabolic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Response To Follicle-stimulating Hormone FMN Binding Amino-acid Betaine Metabolic Process Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Chondrocyte Differentiation Cellular Response To Gonadotropin Stimulus Nitric Oxide Biosynthetic Process Regulation Of Hormone Biosynthetic Process Response To Gonadotropin Endoplasmic Reticulum Membrane Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Cartilage Development Regulation Of Hormone Metabolic Process Positive Regulation Of Steroid Biosynthetic Process NADP Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Steroid Metabolic Process Response To Dexamethasone Regulation Of Chondrocyte Differentiation Electron Transfer Activity Flavin Adenine Dinucleotide Binding Endoplasmic Reticulum Regulation Of Cartilage Development Enzyme Activator Activity Fatty Acid Oxidation Regulation Of Steroid Biosynthetic Process Lipid Oxidation Regulation Of Smoothened Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Electron Transport Chain Regulation Of Steroid Metabolic Process Xenobiotic Metabolic Process
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