POR and CYP17A1

Number of citations of the paper that reports this interaction (PMID 9888582)
3

Data Source:
HPRD (in vivo)

		POR	CYP17A1
Gene Name		P450 (cytochrome) oxidoreductase	cytochrome P450, family 17, subfamily A, polypeptide 1
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Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Axon Neuronal Cell Body
	Molecular Function	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Iron Ion Binding Protein Binding Nitric Oxide Dioxygenase Activity Electron Carrier Activity FMN Binding Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding	Steroid 17-alpha-monooxygenase Activity Iron Ion Binding Oxygen Binding Heme Binding 17-alpha-hydroxyprogesterone Aldolase Activity
	Biological Process	Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Response To Nutrient Carnitine Metabolic Process Flavonoid Metabolic Process Internal Peptidyl-lysine Acetylation Fatty Acid Oxidation Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Monooxygenase Activity Response To Drug Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Oxidation-reduction Process Negative Regulation Of Lipase Activity Demethylation Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Steroid Hormone Biosynthetic Process Cellular Organofluorine Metabolic Process	Steroid Biosynthetic Process Androgen Biosynthetic Process Glucocorticoid Biosynthetic Process Xenobiotic Metabolic Process Sex Differentiation Steroid Metabolic Process Response To Herbicide Response To Acetate Response To Ionizing Radiation Sterol Metabolic Process Response To Insecticide Biphenyl Metabolic Process Dibenzo-p-dioxin Metabolic Process Phenol-containing Compound Metabolic Process Phthalate Metabolic Process Hippocampus Development Adrenal Gland Development Ovulation Response To Nutrient Levels Response To Retinoic Acid Leydig Cell Differentiation Response To Cytokine Hormone Biosynthetic Process Progesterone Metabolic Process Response To Drug Small Molecule Metabolic Process Response To Steroid Hormone Response To CAMP Response To Methylmercury Oxidation-reduction Process Response To Fungicide Cellular Response To Lipopolysaccharide Cellular Response To Antibiotic Cellular Response To Gonadotropin Stimulus Positive Regulation Of Steroid Hormone Biosynthetic Process
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Glucocorticoid biosynthesis Metabolic disorders of biological oxidation enzymes Androgen biosynthesis Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs		Flavin-Adenine Dinucleotide Riboflavin Monophosphate 2\'-Monophosphoadenosine 5\'-Diphosphoribose	NADH Progesterone Abiraterone
Diseases
GWAS			Blood pressure ( 21572416 21909110) Coronary heart disease ( 21378990) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Systolic blood pressure ( 19430479 19430483 21909115)
Protein-Protein Interactions		14 interactors: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 FANCC HMOX1 RABEPK STAT1 XRCC6	8 interactors: ATP5E BARX1 CDO1 CYB5A HSP90AB1 POR RPAIN TIGD7
Entrez ID		5447	1586
HPRD ID		00485	01944
Ensembl ID		ENSG00000127948	ENSG00000148795
Uniprot IDs		E7EVY7 F5H468 P16435	P05093 Q1HB44
PDB IDs		1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT	2C17 3RUK 3SWZ
Enriched GO Terms of Interacting Partners?		Monoterpenoid Metabolic Process Exogenous Drug Catabolic Process Drug Catabolic Process Drug Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Epoxygenase P450 Pathway Steroid Metabolic Process Arachidonic Acid Metabolic Process Response To Drug Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Isoprenoid Metabolic Process Oxidative Demethylation Oxidation-reduction Process Omega-hydroxylase P450 Pathway Fatty Acid Metabolic Process Alkaloid Metabolic Process Carboxylic Acid Metabolic Process Demethylation Small Molecule Metabolic Process Organic Acid Metabolic Process Response To Inorganic Substance Lipid Metabolic Process Monocarboxylic Acid Metabolic Process Cellular Lipid Metabolic Process Alkaloid Catabolic Process Catabolic Process Response To Reactive Oxygen Species Heterocycle Metabolic Process Response To Cadmium Ion Response To Stimulus Coumarin Metabolic Process Cellular Response To Stimulus Dibenzo-p-dioxin Metabolic Process Cellular Response To Cadmium Ion Response To Oxidative Stress Steroid Catabolic Process Cellular Metabolic Process Androgen Metabolic Process Porphyrin-containing Compound Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cellular Organofluorine Metabolic Process Negative Regulation Of Macrophage Fusion Oxidative Deethylation Response To Acetate Toxin Biosynthetic Process Response To Lipopolysaccharide	Cellular Organofluorine Metabolic Process Nitrate Catabolic Process Nitric Oxide Catabolic Process Oxidation-reduction Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Taurine Biosynthetic Process Nitrate Metabolic Process L-cysteine Catabolic Process Hydrogen Ion Transmembrane Transport Proton Transport Positive Regulation Of Cholesterol Biosynthetic Process Taurine Metabolic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Cysteine Metabolic Process Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Cellular Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Organic Acid Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation L-ascorbic Acid Metabolic Process Carnitine Metabolic Process Negative Regulation Of Proteolysis Sulfur Amino Acid Catabolic Process Serine Family Amino Acid Catabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Positive Regulation Of Cell Size Negative Regulation Of Protein Processing Mitochondrial ATP Synthesis Coupled Proton Transport Amino-acid Betaine Metabolic Process Regulation Of Protein Import Into Nucleus, Translocation Negative Regulation Of Lipase Activity Regulation Of Cholesterol Biosynthetic Process Transport Regulation Of Protein Processing
Tagcloud ?		5c 7h adjuvant aluminiumphosphate bactericidal class deoxycholate donors engineered extraction final formulated genetically meningococcal mixed omps omv outer p1 pora prepared represent safe serogroup served strains vaccine vaccines vesicles	acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde pde11a pde2a pde3a pde3b pde4a pde4d phosphodiesterase select splicing xrn2
Tagcloud (Difference) ?		5c 7h adjuvant aluminiumphosphate bactericidal class deoxycholate donors engineered extraction final formulated genetically meningococcal mixed omps omv outer p1 pora prepared represent safe serogroup served strains vaccine vaccines vesicles	acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde pde11a pde2a pde3a pde3b pde4a pde4d phosphodiesterase select splicing xrn2
Tagcloud (Intersection) ?