AP1G2 and SYNRG

Number of citations: 43 (PubMedID 10477754)
Data Source: HPRD (in vitro)

		AP1G2	SYNRG
Name		adaptor related protein complex 1 subunit gamma 2	synergin gamma
Structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Golgi-associated Vesicle Endosome Membrane Membrane Membrane Coat AP-1 Adaptor Complex Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Synapse Intracellular Vesicle	Cytoplasm Golgi Apparatus Membrane AP-1 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Protein Binding
	Biological Process	Intracellular Protein Transport Golgi To Vacuole Transport Protein Transport Vesicle-mediated Transport	Intracellular Protein Transport Endocytosis Protein Transport
Pathways		Lysosome Vesicle Biogenesis	None
GWAS		Blood protein levels ( 30072576 ) Sudden cardiac arrest ( 21658281 )	Lymphocyte count ( 32888494 ) Ovarian cancer ( 23535730 ) Response to angiotensin II receptor blocker therapy ( 22566498 )
Novel Interactors		None recorded	1 novel interactors: ARL6
Interacting Genes		13 interacting genes: AFTPH AP1S1 AP1S2 ATXN1L CENPK DANCR KDM1A NEDD4 PRMT6 RABEP1 SNCA SYNRG XRN1	8 interacting genes: AP1G1 AP1G2 APPBP2 CCDC91 GGA1 GGA2 GGA3 SCAMP1
Entrez ID		8906	11276
HPRD ID		04638	06291
Ensembl ID		ENSG00000213983	ENSG00000275066
Uniprot IDs		O75843 Q86U03 Q86V28	Q9UMZ2
PDB IDs		2E9G 2YMT 3ZHF 4BCX	2MX7
GO Terms Enriched among Interactors		AP-1 Adaptor Complex Endocytosis Clathrin Adaptor Activity Trans-Golgi Network Membrane Protein Transport Import Into Cell Melanosome Assembly Vesicle-mediated Transport Platelet Dense Granule Organization Establishment Of Protein Localization Membrane Coat Cytoplasmic Vesicle Receptor-mediated Endocytosis Cytoplasmic Vesicle Membrane Cellular Localization Terminal Bouton Melanosome Organization Establishment Of Localization In Cell Intracellular Protein Transport Pigment Granule Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Negative Regulation Of Transcription By RNA Polymerase II Formation Of Structure Involved In A Symbiotic Process Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Stem Cell Proliferation Cellular Response To Puromycin Cellular Response To Cycloheximide Histone H2AR3 Methyltransferase Activity Intracellular Protein Localization Secretory Granule Organization Intracellular Transport Clathrin-coated Pit Receptor Internalization Channel Inhibitor Activity Perinuclear Region Of Cytoplasm Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Clathrin-coated Vesicle Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Early Endosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Post-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Trans-Golgi Network Establishment Of Localization In Cell Intracellular Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization To Plasma Membrane Cellular Localization Golgi To Vacuole Transport Membrane Coat Protein Localization To Cell Surface Golgi Apparatus Golgi To Plasma Membrane Protein Transport Vacuolar Transport Cytoplasmic Vesicle Membrane Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Golgi To Plasma Membrane Transport Clathrin-coated Vesicle Small GTPase Binding Endosome Membrane Protein Localization To Membrane Golgi To Lysosome Transport AP-1 Adaptor Complex Ubiquitin Binding Endosome Phosphatidylinositol Binding Lysosomal Transport Cytosolic Transport Clathrin Adaptor Activity Vesicle-mediated Transport To The Plasma Membrane Intracellular Vesicle Localization Within Membrane Early Endosome Membrane Membrane Protein Localization To Cilium Early Endosome Synaptic Vesicle Budding From Endosome Recycling Endosome Membrane Trans-Golgi Network Membrane Protein Transport From Ciliary Membrane To Plasma Membrane Recycling Endosome Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Lysosomal Protein Catabolic Process