SSH1 and ACTB

Number of citations of the paper that reports this interaction (PMID 11832213)
123

Data Source:
HPRD (in vivo)

		SSH1	ACTB
Gene Name		slingshot protein phosphatase 1	actin, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Midbody Cleavage Furrow	Nuclear Chromatin Extracellular Space Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Axon Ribonucleoprotein Complex Cortical Cytoskeleton NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Protein Complex Extracellular Vesicular Exosome MLL5-L Complex Blood Microparticle
	Molecular Function	DNA Binding Actin Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Tat Protein Binding Nucleosomal DNA Binding Nitric-oxide Synthase Binding
	Biological Process	Cell Morphogenesis Protein Dephosphorylation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Lamellipodium Assembly Actin Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Peptidyl-tyrosine Dephosphorylation Regulation Of Axonogenesis Cellular Response To ATP	Retina Homeostasis Chromatin Organization Protein Folding Movement Of Cell Or Subcellular Component Axon Guidance Blood Coagulation Substantia Nigra Development Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ATP-dependent Chromatin Remodeling Cellular Protein Metabolic Process Innate Immune Response Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway 'de Novo' Posttranslational Protein Folding Membrane Organization Platelet Aggregation
Pathways			Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 HATs acetylate histones VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Folding of actin by CCT/TriC Innate Immune System Cell junction organization Protein folding Formation of annular gap junctions Chromatin organization Gap junction trafficking Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes Signaling by VEGF Chaperonin-mediated protein folding Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ACTB CFL1 CFL2 CORO1B DSTN	138 interactors: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 AIMP2 ALOX5 ANXA7 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAP2 CAPZA1 CCT2 CCT4 CCT5 CCT8 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CSNK1A1 CSNK2B CTGF DMTN DNASE1 DSTN DYNLL1 EEF1A1 EHHADH EMD EP300 ERG EZR FABP4 FHL3 FLII GAPDH GNA12 GSN H2AFX HCK HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 KHDRBS1 LASP1 LGALS13 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MX1 MYO18B MYO1E MYOC NCALD NCF1 NCF2 NEBL NOS2 NRAP NSMAF NT5E P2RX7 PCYT1A PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN RAB4A RAC1 RAC2 RCC1 RPL10A S100A11 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTBN2 SSH1 SSH2 SSH3 STX4 SYNJ2BP TANC1 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TTR VHL VSNL1 WASF1 WASF2 WASF3 WDYHV1 XPO6
Entrez ID		54434	60
HPRD ID		09486	00032
Ensembl ID		ENSG00000084112	ENSG00000075624
Uniprot IDs		Q8WYL5	B3KWQ3 P60709 Q1KLZ0
PDB IDs			3BYH 3D2U 3LUE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Actin Filament Depolymerization Actin Filament Depolymerization Positive Regulation Of Protein Depolymerization Positive Regulation Of Protein Complex Disassembly Actin Filament Organization Regulation Of Actin Filament Depolymerization Regulation Of Actin Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Actin Filament-based Process Regulation Of Protein Depolymerization Regulation Of Cytoskeleton Organization Regulation Of Protein Complex Disassembly Actin Cytoskeleton Organization Actin Filament-based Process Cellular Protein Complex Disassembly Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Protein Complex Disassembly Regulation Of Actin Filament Length Regulation Of Organelle Organization Regulation Of Dendritic Spine Morphogenesis Cytoskeleton Organization Regulation Of Cellular Component Size Regulation Of Dendritic Spine Development Organelle Organization Positive Regulation Of Organelle Organization Movement Of Cell Or Subcellular Component Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Regulation Of Dendrite Morphogenesis Wound Healing Chemotaxis Ephrin Receptor Signaling Pathway Regulation Of Dendrite Development Regulation Of Cellular Component Organization Response To Wounding Protein Localization To Cell Leading Edge Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Ameboidal-type Cell Migration Positive Regulation Of Lamellipodium Morphogenesis Platelet Activation Actin Filament Branching Cell Projection Organization Phagocytosis Fc Receptor Signaling Pathway Regulation Of Lamellipodium Morphogenesis Locomotion Immune Response-activating Cell Surface Receptor Signaling Pathway	Regulation Of Cellular Component Organization Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Organelle Organization Regulation Of Cellular Component Size Developmental Process Cell Differentiation Anatomical Structure Development Cell Development Positive Regulation Of Cytoskeleton Organization Anatomical Structure Morphogenesis Regulation Of Actin Filament Polymerization Actin Filament Organization Positive Regulation Of Organelle Organization System Development Negative Regulation Of Actin Filament Polymerization Regulation Of Cell Morphogenesis Multicellular Organismal Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Polymerization Regulation Of Protein Complex Assembly Regulation Of Cell Projection Assembly Cellular Component Assembly Cellular Process Movement Of Cell Or Subcellular Component Regulation Of Cell Projection Organization Regulation Of Lamellipodium Assembly Platelet Activation Regulation Of Actin Filament Depolymerization Negative Regulation Of Protein Complex Assembly Regulation Of Cellular Process Cell Morphogenesis Wound Healing Positive Regulation Of Cellular Component Biogenesis Response To Wounding Regulation Of Stress Fiber Assembly Hemostasis Response To Stimulus Cell Death Death Positive Regulation Of Stress Fiber Assembly Apoptotic Process Cell Projection Organization
Tagcloud ?		10mum 20days aging cofilin1 compartments cytoskeleton decline dysregulation inactivation interestingly knock lim limk1 mef mefdko occurring pcns plasticity presenilin ps1 regard remodeling rescued safely secretase shed shh1 slingshot stream	18s algorithms bestkeeper cancerous circumstances comparisons examining expressional fluctuated gapdh genorm geometric hspcb lipofectamine normalization normalized normfinder powerful qpcr ranking reagent reagents reference reffinder stably studying thirteen transfection valid
Tagcloud (Difference) ?		10mum 20days aging cofilin1 compartments cytoskeleton decline dysregulation inactivation interestingly knock lim limk1 mef mefdko occurring pcns plasticity presenilin ps1 regard remodeling rescued safely secretase shed shh1 slingshot stream	18s algorithms bestkeeper cancerous circumstances comparisons examining expressional fluctuated gapdh genorm geometric hspcb lipofectamine normalization normalized normfinder powerful qpcr ranking reagent reagents reference reffinder stably studying thirteen transfection valid
Tagcloud (Intersection) ?