POLD4 and DTL

Number of citations of the paper that reports this interaction (PubMedID 24022480)
31

Data Source:
BioGRID (enzymatic study)

		POLD4	DTL
Description		DNA polymerase delta 4, accessory subunit	denticleless E3 ubiquitin protein ligase adapter
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Delta DNA Polymerase Complex	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	DNA Synthesis Involved In DNA Repair Positive Regulation Of Endothelial Cell Proliferation DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To UV Positive Regulation Of Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Ubiquitination Translesion Synthesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Recognition of DNA damage by PCNA-containing replication complex Neddylation
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Height ( 20881960) Large artery stroke ( 28265093) Nickel levels ( 26025379) Plateletcrit ( 32888494)
Interacting Genes		9 interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1	17 interacting genes: ATR CDK1 CDK2 CDKN1A CDT1 CHEK1 DDB1 KAT2A KMT5A PCNA POLD4 POLH TDG TOB1 TP53 UBE2D1 UBE2N
Entrez ID		57804	51514
HPRD ID		17873	17952
Ensembl ID		ENSG00000175482	ENSG00000143476
Uniprot IDs		Q6NSD7 Q9HCU8	B4E0E6 F5GZ90 Q9NZJ0
PDB IDs		6HVO 6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB	6QC0
Enriched GO Terms of Interacting Partners?		DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process DNA Replication Translesion Synthesis Postreplication Repair DNA Repair DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Metabolic Process DNA Strand Elongation DNA Damage Response Delta DNA Polymerase Complex Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Biosynthetic Process Base-excision Repair, Gap-filling Cellular Response To Stress DNA-directed DNA Polymerase Activity Nucleic Acid Metabolic Process DNA Replication Proofreading Macromolecule Biosynthetic Process Chromosome, Telomeric Region Leading Strand Elongation Zeta DNA Polymerase Complex Nucleobase-containing Compound Metabolic Process Response To Stress Error-prone Translesion Synthesis DNA Polymerase Activity Response To Radiation Response To UV Chromatin Binding Mismatch Repair 4 Iron, 4 Sulfur Cluster Binding Macromolecule Metabolic Process PCNA Complex Damaged DNA Binding Replisome Response To Light Stimulus Iron-sulfur Cluster Binding Nucleoplasm Cellular Response To UV PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleotidyltransferase Activity Cellular Response To Light Stimulus Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Regulation Of DNA Replication DNA Synthesis Involved In UV-damage Excision Repair Regulation Of DNA Metabolic Process	Regulation Of DNA Metabolic Process DNA Metabolic Process DNA Repair DNA Damage Response DNA Replication Regulation Of DNA Replication Cellular Response To Stress Negative Regulation Of Cell Cycle Process Cellular Response To UV DNA Damage Checkpoint Signaling Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Cellular Response To Light Stimulus Nucleoplasm Chromatin Organization Replicative Senescence Negative Regulation Of Cell Cycle Phase Transition Nucleic Acid Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Repair Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Positive Regulation Of DNA Metabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Signaling Response To UV Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Chromosome, Telomeric Region Replication Fork Regulation Of Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleus Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Fibroblast Proliferation Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA Metabolic Process G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle
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