POLD4

Gene Name		polymerase (DNA-directed), delta 4, accessory subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: PCNA POLD1 POLD2 POLD3 POLE SEC23IP WRNIP1
Entrez ID		57804
HPRD ID		17873
Ensembl ID
Uniprot IDs		Q6NSD7 Q9HCU8
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Base-excision Repair DNA Synthesis Involved In DNA Repair Telomere Maintenance DNA Replication Nucleotide-excision Repair DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Mismatch Repair DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Homeostasis Cellular Response To Stress Mitotic Cell Cycle Base-excision Repair, Gap-filling Chromosome Organization Cell Cycle Process Cell Cycle Homeostatic Process Organelle Organization Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Deoxyribonuclease Activity DNA Replication Proofreading Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Leading Strand Elongation Regulation Of DNA Replication Nitrogen Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of DNA-dependent DNA Replication Initiation Cell Cycle Phase Transition Cellular Response To Stimulus Translesion Synthesis Fatty Acid Homeostasis
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