POLE and POLE2

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (pull down, biochemical)

		POLE	POLE2
Gene Name		polymerase (DNA directed), epsilon, catalytic subunit	polymerase (DNA directed), epsilon 2, accessory subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Epsilon DNA Polymerase Complex	Nucleoplasm Epsilon DNA Polymerase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Zinc Ion Binding 4 Iron, 4 Sulfur Cluster Binding	DNA Binding DNA-directed DNA Polymerase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair In Utero Embryonic Development DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis
Pathways		Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases	Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE3 POLE4 RAD17 STK19 TOPBP1 XRCC5	13 interactors: AGFG1 C14orf1 EEF1A1 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 TBX15 TLE1 TRIM27
Entrez ID		5426	5427
HPRD ID		07177	16007
Ensembl ID		ENSG00000177084	ENSG00000100479
Uniprot IDs		F5H1D6 Q07864	P56282
PDB IDs			2V6Z
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Biosynthetic Process DNA Replication Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA-dependent DNA Replication DNA Repair Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling DNA Recombination Cellular Response To Stress Chromosome Organization Leading Strand Elongation Transcription-coupled Nucleotide-excision Repair Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cell Cycle Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Translesion Synthesis Mitotic Cell Cycle Process Nucleotide-excision Repair Nitrogen Compound Metabolic Process Cellular Metabolic Process Postreplication Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Stress Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Biosynthetic Process DNA Replication Initiation Histone H3 Acetylation Peptidyl-lysine Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Homeostasis Organelle Organization Cell Proliferation Homeostatic Process Mismatch Repair	Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Interleukin-2 Production Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Microtubule Plus-end Binding DNA Biosynthetic Process Histone Acetylation Chromosome Organization Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cytokine Production Regulation Of Cytokine Production Negative Regulation Of Calcium Ion Import Regulation Of Transcription, DNA-templated Base-excision Repair, Gap-filling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Localization To Microtubule Regulation Of RNA Metabolic Process Interferon-gamma Secretion Negative Regulation Of Cytokine Production Regulation Of Gene Expression, Epigenetic Chromatin Organization Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Gene Expression
Tagcloud ?		absolute bfgf bmp cdnas disruption dorsal embryo embryogenesis explants fate globin helix hematopoietic inductive lineages marginal mesoderm myod organogenesis participates patterning progenitors requirement scl specify specifying ventral xenopus zone	algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated
Tagcloud (Difference) ?		absolute bfgf bmp cdnas disruption dorsal embryo embryogenesis explants fate globin helix hematopoietic inductive lineages marginal mesoderm myod organogenesis participates patterning progenitors requirement scl specify specifying ventral xenopus zone	algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated
Tagcloud (Intersection) ?