RBM11 and MADD

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RBM11	MADD
Description		RNA binding motif protein 11	MAP kinase activating death domain
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Cytoplasm Cytosol Plasma Membrane Membrane Axon Cell Projection
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Protein Binding Poly(U) RNA Binding Protein Homodimerization Activity	Guanyl-nucleotide Exchange Factor Activity Death Receptor Binding Protein Binding Protein Kinase Activator Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cell Differentiation Cellular Response To Oxidative Stress	Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Rab Protein Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) C-reactive protein levels ( 30388399) Chronic kidney disease ( 26831199) Chronotype ( 30696823) Corneal astigmatism ( 29422769) Fasting blood glucose ( 20081858 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 34059833) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 29891935) Glycemic traits (pleiotropy) ( 31021400) HDL cholesterol ( 25961943 19060911) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Insulin-related traits (multivariate analysis) ( 32002517) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Monocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Proinsulin levels ( 21873549) Refractive error ( 32231278)
Interacting Genes		78 interacting genes: ACOT1 APP ATIC ATOSB ATRX BHLHE40 CEP85 CERCAM CHCHD3 CHD6 CNTNAP1 COPA CRYAB DALRD3 DAZAP2 DCAF8 DDX27 DDX6 DST DTX2 EDIL3 ENKD1 FN3K GABPB1 GADD45GIP1 GLIS2 GPATCH2L HERPUD2 HMG20A LRP1 MADD MAN1A2 MECOM MED13L METAP1 MYO15B NEFL NMT2 PCBP1 PCM1 PCYT1A PDHB PIBF1 PLCG1 PLEKHB1 POLG PRRC2A PSMD4 QKI RBFOX3 RHOXF2 RNF38 SAXO4 SCNM1 SCYL2 SF3B2 SNRNP70 SNRPA SNRPC SPRED1 STAMBP TUBB4A U2AF2 VIM ZCCHC8 ZFHX3 ZKSCAN5 ZMYND10 ZNF189 ZNF214 ZNF251 ZNF302 ZNF329 ZNF414 ZNF606 ZNF7 ZNF774 ZNF83	12 interacting genes: NPDC1 PCNT PIDD1 POT1 PTPRN RB1CC1 RBM11 TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ
Entrez ID		54033	8567
HPRD ID		10185	04664
Ensembl ID		ENSG00000185272	ENSG00000110514
Uniprot IDs		P57052	A0A0A0MRB5 A0A0U1RR25 A0A9L9PXF1 A0A9L9PXN0 A0A9L9PXZ0 A0A9L9PXZ3 A0A9L9PY18 A0A9L9PY22 Q8WXG6
PDB IDs		2YWK
Enriched GO Terms of Interacting Partners?		Nucleus RNA Splicing, Via Transesterification Reactions U1 SnRNA Binding MRNA Splicing, Via Spliceosome DNA Binding Spliceosomal Complex Zinc Ion Binding RNA Splicing Metal Ion Binding Nucleic Acid Binding U2-type Prespliceosome U1 SnRNP Regulation Of RNA Metabolic Process Astrocyte Activation Involved In Immune Response MRNA Binding MRNA Processing Commitment Complex Microtubule-based Process Stress Granule Assembly U1 SnRNP Binding	Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Death Receptor Activity TRAIL Binding Cellular Response To Mechanical Stimulus TRAIL-activated Apoptotic Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Cell Death Programmed Cell Death Response To Mechanical Stimulus Activation Of Protein Kinase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death TRAIL Receptor Activity Ribophagy Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Signaling Receptor Activity Regulation Of Canonical NF-kappaB Signal Transduction Synaptic Target Recognition Positive Regulation Of Telomeric Loop Disassembly Dense Core Granule Maturation 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Endopeptidase Complex Response To Stress Secretory Granule Maturation Positive Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Telomeric D-loop Binding Telomere Assembly Protein Retention In Golgi Apparatus Cellular Response To Stress Golgi Reassembly Single-stranded Telomeric DNA Binding Positive Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Aortic Valve Development Semi-lunar Valve Development Phosphoserine Residue Binding Positive Regulation Of Kinase Activity Shelterin Complex Organelle Organization
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