RBM11 and ZFHX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RBM11	ZFHX3
Description		RNA binding motif protein 11	zinc finger homeobox 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Protein Binding Poly(U) RNA Binding Protein Homodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cell Differentiation Cellular Response To Oxidative Stress	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Circadian Regulation Of Gene Expression Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Transforming Growth Factor Beta Regulation Of Locomotor Rhythm
Pathways			RUNX3 regulates CDKN1A transcription
Drugs
Diseases
GWAS			Atrial fibrillation ( 30061737 33990960 29892015 28416822 28416818 19597491 19597492 22544366) Behavioural changes in frontotemporal lobe dementia ( 29724592) Body mass index ( 29273807 28892062) Brain morphology (MOSTest) ( 32665545) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Chronotype ( 30696823) Early onset atrial fibrillation ( 28460022) Estimated glomerular filtration rate ( 31015462 31152163 31451708) General risk tolerance (MTAG) ( 30643258) Glucocorticoid-induced osteonecrosis ( 26265699) Heel bone mineral density ( 30598549) Hypospadias ( 25108383) Incident atrial fibrillation ( 28416818) Ischemic stroke (cardioembolic) ( 26708676) Kawasaki disease ( 19132087) LDL cholesterol ( 21347282) Lung function (FVC) ( 30061609) Metabolite levels ( 22916037 23823483) Morning person ( 30696823) Nose morphology ( 29921221) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Prevalent atrial fibrillation ( 28416818) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 33547301) Sick sinus syndrome ( 33580673) Smoking status (ever vs never smokers) ( 30643258) Stroke (ischemic) ( 23041239) Type 2 diabetes ( 32499647)
Interacting Genes		78 interacting genes: ACOT1 APP ATIC ATOSB ATRX BHLHE40 CEP85 CERCAM CHCHD3 CHD6 CNTNAP1 COPA CRYAB DALRD3 DAZAP2 DCAF8 DDX27 DDX6 DST DTX2 EDIL3 ENKD1 FN3K GABPB1 GADD45GIP1 GLIS2 GPATCH2L HERPUD2 HMG20A LRP1 MADD MAN1A2 MECOM MED13L METAP1 MYO15B NEFL NMT2 PCBP1 PCM1 PCYT1A PDHB PIBF1 PLCG1 PLEKHB1 POLG PRRC2A PSMD4 QKI RBFOX3 RHOXF2 RNF38 SAXO4 SCNM1 SCYL2 SF3B2 SNRNP70 SNRPA SNRPC SPRED1 STAMBP TUBB4A U2AF2 VIM ZCCHC8 ZFHX3 ZKSCAN5 ZMYND10 ZNF189 ZNF214 ZNF251 ZNF302 ZNF329 ZNF414 ZNF606 ZNF7 ZNF774 ZNF83	36 interacting genes: ALKBH4 AURKA BHLHE40 CEP70 CNOT2 COPS6 CSTPP1 DEUP1 EFHC2 GOLGA2 GOLGA6L9 HIVEP1 KRT31 KRT34 KRT40 LMNB2 MSX2 MTUS2 MYB NINL PIAS3 PIBF1 PICK1 POU2F1 POU6F2 PRPF40A RBM11 SPECC1L TACC1 TLE5 TRIM27 TRIM54 TRIML2 TTC23 USHBP1 ZNF620
Entrez ID		54033	463
HPRD ID		10185	00075
Ensembl ID		ENSG00000185272	ENSG00000140836
Uniprot IDs		P57052	Q15911 Q8N2Y6
PDB IDs		2YWK	2DA1 2DA2 2DA3
Enriched GO Terms of Interacting Partners?		Nucleus RNA Splicing, Via Transesterification Reactions U1 SnRNA Binding MRNA Splicing, Via Spliceosome DNA Binding Spliceosomal Complex Zinc Ion Binding RNA Splicing Metal Ion Binding Nucleic Acid Binding U2-type Prespliceosome U1 SnRNP Regulation Of RNA Metabolic Process Astrocyte Activation Involved In Immune Response MRNA Binding MRNA Processing Commitment Complex Microtubule-based Process Stress Granule Assembly U1 SnRNP Binding	Cytoskeleton Organization Cytoskeleton Microtubule Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization Mitotic Spindle Organization Microtubule Organizing Center Microtubule Cytoskeleton Organization Involved In Mitosis Structural Constituent Of Skin Epidermis Cilium Disassembly Centrosome Spindle Organization Cell Division Intermediate Filament Meiotic Spindle Assembly Intermediate Filament Organization Organelle Disassembly Microtubule Organizing Center Organization SUMO Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Meiotic Spindle Organization Spindle Assembly Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process
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