GTF2I and C4BPA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GTF2I	C4BPA
Description		general transcription factor IIi	complement component 4 binding protein alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Extracellular Region Extracellular Space Plasma Membrane Blood Microparticle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Binding Protein Binding
	Biological Process	Transcription By RNA Polymerase II Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II	Immune System Process T Cell Mediated Immunity Complement Activation, Classical Pathway Response To Symbiotic Bacterium Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Immune Response Response To Other Organism Regulation Of Opsonization
Pathways			Regulation of Complement cascade
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Atrial fibrillation ( 29892015 30061737) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) Sjögren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 28714469 32771030)	Bell's palsy ( 33602968) C4b binding protein levels ( 20212171) Mean platelet volume ( 27863252 32888494) Platelet distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Venous thromboembolism ( 31420334 31676865)
Interacting Genes		48 interacting genes: AP1B1 AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 CEBPA CTAG1A CTAG1B DNMT3L DPY30 ERCC6 GCC1 HDAC3 JAK2 LINC01554 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 SUMO2 TAB2 TRAF6 TRIM54 UBC UBE2I USF1 USP7 YY1 ZBTB17 ZMYM3	11 interacting genes: APCS BMPR2 FXYD6 GIT2 GTF2I HSP90AA1 LBP LRP1 PROS1 SMARCD1 TXN
Entrez ID		2969	722
HPRD ID		03399	00403
Ensembl ID		ENSG00000263001	ENSG00000123838
Uniprot IDs		A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09	P04003
PDB IDs		2D9B 2DN4 2ED2 2EJE	2A55 4B0F 5HYP 5HYT 5HYU 5HZP 5I0Q 8TCB 8TGT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Response To Cytokine Response To Peptide Intracellular Signaling Cassette Nucleoplasm Intracellular Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Interleukin-6-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Response To Lipid Cellular Response To Cytokine Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Stress Cellular Response To Stress Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gene Expression Nucleobase-containing Compound Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Animal Organ Development Protein Modification Process Negative Regulation Of Biosynthetic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Response To Hormone Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Developmental Process	Chaperone-mediated Protein Complex Assembly Regulation Of Multicellular Organismal Process Acute-phase Response Negative Regulation Of Wound Healing Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Negative Regulation Of Multicellular Organismal Process Acute Inflammatory Response Regulation Of SMAD Protein Signal Transduction Artery Morphogenesis Clathrin-coated Pit Protein Tyrosine Kinase Binding Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis CTP Binding DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Lipopolysaccharide Transport Positive Regulation Of Reverse Cholesterol Transport Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Regulation Of Transcytosis Apolipoprotein Receptor Activity Cellular Detoxification Of Hydrogen Peroxide Blood Vessel Morphogenesis Activin Receptor Activity, Type II Rho GDP-dissociation Inhibitor Binding Lipoprotein Particle Receptor Binding Detoxification Of Hydrogen Peroxide Negative Regulation Of Developmental Process Unfolded Protein Binding Regulation Of Lung Blood Pressure Positive Regulation Of Multicellular Organismal Process Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Nucleocytoplasmic Transport Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Protein-disulfide Reductase [NAD(P)H] Activity Blood Microparticle
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