GTF2I and C4BPA

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GTF2I	C4BPA
Gene Name		general transcription factor IIi	complement component 4 binding protein, alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Cell Projection Neuronal Cell Body	Extracellular Region Extracellular Space Plasma Membrane Other Organism Cell Blood Microparticle
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Mitogen-activated Protein Kinase Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Transition Between Slow And Fast Fiber Negative Regulation Of Angiogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration	Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Opsonization
Pathways			Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS			C4b binding protein levels ( 20212171)
Protein-Protein Interactions		35 interactors: AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 DPY30 GCC1 HDAC3 JAK2 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 TAB2 TRAF6 USF1 YY1 ZBTB17 ZMYM3	9 interactors: APCS BMPR2 FXYD6 GIT2 GTF2I LBP LRP1 PROS1 SMARCD1
Entrez ID		2969	722
HPRD ID		03399	00403
Ensembl ID		ENSG00000077809	ENSG00000123838
Uniprot IDs		A8K9W7 P78347 Q499G6 Q86U51	P04003 Q5VVQ8
PDB IDs		2D9B 2DN4 2ED2 2EJE	2A55 4B0F
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Gene Expression Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Response To Stimulus Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Gene Expression Cellular Response To Stimulus Positive Regulation Of Protein Phosphorylation Growth Hormone Receptor Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Growth Hormone Stimulus MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transferase Activity Cell Communication Multicellular Organismal Development Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process	Regulation Of Locomotion Acute-phase Response Regulation Of Inflammatory Response Artery Development Negative Regulation Of Wound Healing Regulation Of Acute Inflammatory Response Acute Inflammatory Response Beta-amyloid Clearance Regulation Of Metabolic Process Positive Regulation Of Chemotaxis Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Regulation Of Lung Blood Pressure Lipopolysaccharide Transport Transition Between Slow And Fast Fiber Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Behavior Regulation Of Wound Healing Negative Regulation Of Vasoconstriction Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Cell Migration Regulation Of Chemotaxis Regulation Of Cell Motility Regulation Of Cellular Component Movement Regulation Of Behavior Negative Regulation Of Monocyte Differentiation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Respiratory Burst Leukocyte Migration Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Skeletal Muscle Adaptation Lymphatic Endothelial Cell Differentiation Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Growth Negative Regulation Of Locomotion Phagocytosis Chromatin-mediated Maintenance Of Transcription Opsonization Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Regulation Of Phospholipase A2 Activity Positive Regulation Of Macrophage Activation Lymphangiogenesis Response To Stress Positive Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Glycoprotein Metabolic Process
Tagcloud ?		74146970t ab aggressive assessment bap1 carcinomas cdkn2a classification complement cyld delta facilitate indolent isoforms missense mutation next notably pbrm1 rarely recurrent sequencing stimulate subtype subtypes tets thymic thymomas tp53
Tagcloud (Difference) ?		74146970t ab aggressive assessment bap1 carcinomas cdkn2a classification complement cyld delta facilitate indolent isoforms missense mutation next notably pbrm1 rarely recurrent sequencing stimulate subtype subtypes tets thymic thymomas tp53
Tagcloud (Intersection) ?