GTF2I and MAPK12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GTF2I	MAPK12
Description		general transcription factor IIi	mitogen-activated protein kinase 12
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Peptidase Activator Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Transcription By RNA Polymerase II Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II	MAPK Cascade Signal Transduction Muscle Organ Development Cellular Response To Stress Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Myoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Muscle Cell Differentiation Regulation Of Cell Cycle
Pathways			NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway
Drugs			Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) Sjögren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 28714469 32771030)	Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		48 interacting genes: AP1B1 AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 CEBPA CTAG1A CTAG1B DNMT3L DPY30 ERCC6 GCC1 HDAC3 JAK2 LINC01554 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 SUMO2 TAB2 TRAF6 TRIM54 UBC UBE2I USF1 USP7 YY1 ZBTB17 ZMYM3	30 interacting genes: CDK1 DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1
Entrez ID		2969	6300
HPRD ID		03399	03868
Ensembl ID		ENSG00000263001	ENSG00000188130
Uniprot IDs		A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09	P53778
PDB IDs		2D9B 2DN4 2ED2 2EJE	1CM8 4QUM 6UNA 7CGA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Response To Cytokine Response To Peptide Intracellular Signaling Cassette Nucleoplasm Intracellular Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Interleukin-6-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Response To Lipid Cellular Response To Cytokine Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Stress Cellular Response To Stress Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gene Expression Nucleobase-containing Compound Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Animal Organ Development Protein Modification Process Negative Regulation Of Biosynthetic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Response To Hormone Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Developmental Process	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity MAPK Cascade Neuromuscular Junction Intracellular Signal Transduction MAP Kinase Kinase Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Ionotropic Glutamate Receptor Binding Protein Serine/threonine Kinase Activity Establishment Or Maintenance Of Cell Polarity Protein Kinase Binding Intracellular Signaling Cassette Muscle Contraction Signal Transduction Protein Kinase Activity Receptor Localization To Synapse Receptor Clustering Protein Serine Kinase Activity Cytoplasm Cytosol Protein Localization To Synapse Muscle System Process Cellular Senescence Kinase Activity Protein Localization To Cell Junction Response To Metal Ion Calmodulin Binding Negative Regulation Of Cell Cycle Kinase Binding Postsynaptic Density Membrane Cytoplasmic Side Of Plasma Membrane Regulation Of Sodium Ion Transmembrane Transport Regulation Of Chromosome Organization NLRP1 Inflammasome Complex Assembly Phosphoprotein Phosphatase Activity Negative Regulation Of P38MAPK Cascade GMP Kinase Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Cellular Response To Growth Factor Stimulus System Process GDP Metabolic Process Regulation Of Multicellular Organismal Process Chemical Synaptic Transmission Juxtaparanode Region Of Axon Response To Growth Factor Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Sodium Ion Transport Cytoskeletal Protein Binding Cellular Response To Potassium Ion
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