GTF2I and ZMYM3

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (imaging technique, biochemical, two hybrid)

		GTF2I	ZMYM3
Description		general transcription factor IIi	zinc finger MYM-type containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Nucleus Nucleoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Transcription By RNA Polymerase II Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II	Cytoskeleton Organization Regulation Of Cell Morphogenesis
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) Sjögren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 28714469 32771030)
Interacting Genes		48 interacting genes: AP1B1 AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 CEBPA CTAG1A CTAG1B DNMT3L DPY30 ERCC6 GCC1 HDAC3 JAK2 LINC01554 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 SUMO2 TAB2 TRAF6 TRIM54 UBC UBE2I USF1 USP7 YY1 ZBTB17 ZMYM3	7 interacting genes: ABRAXAS1 APP CDK6 GTF2I SUMO1 SUMO2 UIMC1
Entrez ID		2969	9203
HPRD ID		03399	02088
Ensembl ID		ENSG00000263001	ENSG00000147130
Uniprot IDs		A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09	A8K3Z7 Q14202
PDB IDs		2D9B 2DN4 2ED2 2EJE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Response To Cytokine Response To Peptide Intracellular Signaling Cassette Nucleoplasm Intracellular Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Interleukin-6-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Response To Lipid Cellular Response To Cytokine Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Stress Cellular Response To Stress Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gene Expression Nucleobase-containing Compound Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Animal Organ Development Protein Modification Process Negative Regulation Of Biosynthetic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Response To Hormone Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Developmental Process	Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process BRCA1-A Complex Positive Regulation Of Metabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process DNA Damage Response Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Protein Tag Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process Postsynaptic Cytosol Positive Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Presynapse Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Protein Localization To Nucleus Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Protein Sumoylation Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Process Mitotic G2/M Transition Checkpoint Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Glial Cell Development
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