GTF2I and ATF6

Number of citations of the paper that reports this interaction (PubMedID 11287625)
29

Data Source:
HPRD (in vitro, in vivo)

		GTF2I	ATF6
Description		general transcription factor IIi	activating transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription By RNA Polymerase II Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II	Eye Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Signal Transduction Visual Perception Positive Regulation Of Autophagy Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response ERAD Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of ATF6-mediated Unfolded Protein Response
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Modulation of host responses by IFN-stimulated genes
Drugs			Pseudoephedrine
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) Sjögren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 28714469 32771030)	Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909) Parkinson's disease (age of onset) ( 19772629) Severe insulin-deficient type 2 diabetes ( 34737425) Systemic sclerosis ( 30247649)
Interacting Genes		48 interacting genes: AP1B1 AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 CEBPA CTAG1A CTAG1B DNMT3L DPY30 ERCC6 GCC1 HDAC3 JAK2 LINC01554 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 SUMO2 TAB2 TRAF6 TRIM54 UBC UBE2I USF1 USP7 YY1 ZBTB17 ZMYM3	18 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I MAGI1 NFYA NFYC NNMT RNF168 SRF TNFRSF1A UBASH3A XBP1 YY1
Entrez ID		2969	22926
HPRD ID		03399	16118
Ensembl ID		ENSG00000263001	ENSG00000118217
Uniprot IDs		A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09	A0A7P0TAF2 A0A7P0Z421 A8K383 P18850
PDB IDs		2D9B 2DN4 2ED2 2EJE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Response To Cytokine Response To Peptide Intracellular Signaling Cassette Nucleoplasm Intracellular Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Interleukin-6-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Response To Lipid Cellular Response To Cytokine Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Stress Cellular Response To Stress Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gene Expression Nucleobase-containing Compound Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Animal Organ Development Protein Modification Process Negative Regulation Of Biosynthetic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Response To Hormone Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Developmental Process	Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process CCAAT-binding Factor Complex DNA Binding Regulation Of Gene Expression Protein-DNA Complex Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Peptide Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process ATF6-mediated Unfolded Protein Response Hemopoiesis Regulation Of Metabolic Process Myeloid Cell Development Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of MiRNA Transcription Response To Stress Nucleobase-containing Compound Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Stress Nucleoplasm Response To Unfolded Protein Regulation Of MiRNA Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Associative Learning Regulation Of Cellular Response To Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?