GTF2I and AP4S1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GTF2I	AP4S1
Description		general transcription factor IIi	adaptor related protein complex 4 subunit sigma 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Cytoplasm Golgi Apparatus Trans-Golgi Network Endomembrane System Membrane AP-4 Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Transcription By RNA Polymerase II Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II	Protein Targeting Intracellular Protein Localization Protein Transport Vesicle-mediated Transport
Pathways			Lysosome Vesicle Biogenesis
Drugs
Diseases			Cerebral palsy
GWAS		Atrial fibrillation ( 29892015 30061737) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) Sjögren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 28714469 32771030)	Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494)
Interacting Genes		48 interacting genes: AP1B1 AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 CEBPA CTAG1A CTAG1B DNMT3L DPY30 ERCC6 GCC1 HDAC3 JAK2 LINC01554 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 SUMO2 TAB2 TRAF6 TRIM54 UBC UBE2I USF1 USP7 YY1 ZBTB17 ZMYM3	6 interacting genes: AFP APP GRB2 GTF2I HTR6 TEAD3
Entrez ID		2969	11154
HPRD ID		03399	06257
Ensembl ID		ENSG00000263001	ENSG00000100478
Uniprot IDs		A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09	Q9Y587
PDB IDs		2D9B 2DN4 2ED2 2EJE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Response To Cytokine Response To Peptide Intracellular Signaling Cassette Nucleoplasm Intracellular Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Interleukin-6-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Response To Lipid Cellular Response To Cytokine Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Stress Cellular Response To Stress Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gene Expression Nucleobase-containing Compound Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Animal Organ Development Protein Modification Process Negative Regulation Of Biosynthetic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Response To Hormone Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Developmental Process	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Glial Cell Development Guanyl-nucleotide Exchange Factor Adaptor Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Grb2-EGFR Complex Asymmetric Neuroblast Division Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Supramolecular Fiber Organization Cellular Response To Norepinephrine Stimulus Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Neurotrophin TRKA Receptor Binding Histamine Receptor Activity Axon Choice Point Recognition Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heparan Sulfate Binding Signaling Receptor Activator Activity Ovulation From Ovarian Follicle Peptidase Activator Activity
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