EXOSC9 and MPP6

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
HPRD (in vivo)

		EXOSC9	MPP6
Gene Name		exosome component 9	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding AU-rich Element Binding Poly(A) RNA Binding	Protein Binding PDZ Domain Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RRNA Processing Immune Response Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Protein Complex Assembly
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 MPP6 SKIV2L2 UBE2I ZDHHC17	28 interactors: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 NDN NFKB1 PARN RPS20 SKIV2L2 SMARCA4 SNX9 THOP1
Entrez ID		5393	51678
HPRD ID		07315	09509
Ensembl ID		ENSG00000123737	ENSG00000105926
Uniprot IDs		B4DXG8 Q06265	B8ZZG1 Q9NZW5
PDB IDs		2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ribosome Biogenesis Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process NcRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of 5.8S RRNA Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process DNA Deamination RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process CUT Catabolic Process Catabolic Process Nuclear MRNA Surveillance Gene Expression RNA Surveillance Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis RRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Modification Nitrogen Compound Metabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Cellular Metabolic Process TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Localization SnoRNA Metabolic Process RRNA 3'-end Processing Intracellular MRNA Localization Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Processing Positive Regulation Of Cell Growth Metabolic Process Isotype Switching	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis RRNA Processing RRNA Metabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process Nuclear MRNA Surveillance NcRNA Metabolic Process RNA Surveillance RRNA Catabolic Process Cellular Macromolecule Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Maturation Of 5.8S RRNA Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Gene Expression RNA Metabolic Process DNA Deamination Catabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Growth Histone MRNA Catabolic Process Regulation Of Growth Intracellular MRNA Localization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-lipid Complex Assembly Histone MRNA Metabolic Process Membrane Organization Positive Regulation Of Cell Growth Cellular Process RNA Processing Cellular Metabolic Process Regulation Of Cholesterol Transport Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Interleukin-12 Biosynthetic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		balance compartment degradation differentiation done enriched epidermal exosome grhl3 loss maintain maintaining maintains maintenance mammalian necessary pm premature prevent prevents progenitor proliferative promotes regulating renewal reside retain transcript understood	binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease exosome functionally gfp groove helicase insight interface intertwined mtr4 physically revealing ribonuclease rnas rrp47 rrp6 structural synergize turnover
Tagcloud (Difference) ?		balance compartment degradation differentiation done enriched epidermal grhl3 loss maintain maintaining maintains maintenance mammalian necessary pm premature prevent prevents progenitor proliferative promotes regulating renewal reside retain transcript understood	binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease functionally gfp groove helicase insight interface intertwined mtr4 physically revealing ribonuclease rnas rrp47 rrp6 structural synergize turnover
Tagcloud (Intersection) ?		exosome