EXOSC9 and EXOSC7

Number of citations of the paper that reports this interaction (PubMedID 11719186)
0

Data Source:
HPRD (in vivo, two hybrid)

		EXOSC9	EXOSC7
Description		exosome component 9	exosome component 7
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome Nucleolar Exosome (RNase Complex) Exoribonuclease Complex	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process Immune Response RRNA Catabolic Process Positive Regulation Of Cell Growth U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Positive Regulation Of Transcription By RNA Polymerase II Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 32888494)	Acne (severe) ( 24927181) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862)
Interacting Genes		21 interacting genes: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 ERG EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 HBS1L MTREX PALS2 SETX SUMO2 UBE2I ZDHHC17	46 interacting genes: ALG13 APP C1orf35 CCDC59 DIS3 DMRTB1 DPYSL2 DXO EHMT2 EIF4ENIF1 ESRRG ESS2 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 EXOSC9 HOOK1 IP6K1 KIF24 KRT31 LARP4 MIF MTREX PALS2 PRC1 PRPF6 PRRC2B PTEN RALYL RBM22 RBM7 RBPMS RPA2 RPL21 SNRNP48 SNW1 SUPT5H TFIP11 THOC1 UBE2K UNKL VIM
Entrez ID		5393	23016
HPRD ID		07315	09401
Ensembl ID		ENSG00000123737	ENSG00000075914
Uniprot IDs		B4DXG8 Q06265	B2RDZ9 Q15024
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity U4 SnRNA 3'-end Processing RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nuclear RNA Surveillance RNA Surveillance MRNA Catabolic Process SnRNA 3'-end Processing Nuclear MRNA Surveillance SnRNA Metabolic Process Nucleobase-containing Compound Catabolic Process SnRNA Processing RRNA Catabolic Process MRNA Metabolic Process RRNA Processing RRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Macromolecule Catabolic Process 3'-5'-RNA Exonuclease Activity RNA Metabolic Process RNA Processing RNA Binding RNA 3'-end Processing Sno(s)RNA Metabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RRNA 3'-end Processing TRNA Decay DNA Deamination Catabolic Process Nucleolus Nucleobase-containing Compound Metabolic Process CUT Catabolic Process Nucleoplasm DNA Modification Negative Regulation Of Gene Expression U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing MRNA 3'-UTR AU-rich Region Binding Nucleus Negative Regulation Of Macromolecule Biosynthetic Process	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity Nuclear RNA Surveillance RNA Binding RNA Surveillance U4 SnRNA 3'-end Processing SnRNA Metabolic Process RNA Catabolic Process MRNA Metabolic Process RRNA Catabolic Process RNA Processing Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process SnRNA 3'-end Processing MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process 3'-5'-RNA Exonuclease Activity RRNA Processing SnRNA Processing Exoribonuclease Complex Sno(s)RNA Metabolic Process RRNA Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Nucleic Acid Metabolic Process RNA 3'-end Processing Nucleoplasm RRNA 3'-end Processing TRNA Decay Nucleobase-containing Compound Metabolic Process Nucleus Macromolecule Metabolic Process Catalytic Step 2 Spliceosome SnRNA Catabolic Process CUT Catabolic Process Macromolecule Catabolic Process Spliceosomal Complex DNA Deamination RNA Splicing Nucleolus Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA
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