EXOSC9 and DDX39A

Number of citations of the paper that reports this interaction (PubMedID 14667819)
0

Data Source:
HPRD (two hybrid)

		EXOSC9	DDX39A
Description		exosome component 9	DExD-box helicase 39A
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome Nucleolar Exosome (RNase Complex) Exoribonuclease Complex	Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Speck
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process Immune Response RRNA Catabolic Process Positive Regulation Of Cell Growth U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Positive Regulation Of Transcription By RNA Polymerase II Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway	MRNA Splicing, Via Spliceosome Toll-like Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing Negative Regulation Of Innate Immune Response Negative Regulation Of RNA Export From Nucleus
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 32888494)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		21 interacting genes: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 ERG EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 HBS1L MTREX PALS2 SETX SUMO2 UBE2I ZDHHC17	14 interacting genes: CCL14 CEBPA DDX39B EXOSC9 HIPK2 HNRNPLL PTK2 RNF4 SARNP SAT1 SUMO2 TERF1 TERF2IP UBE2I
Entrez ID		5393	10212
HPRD ID		07315	10861
Ensembl ID		ENSG00000123737	ENSG00000123136
Uniprot IDs		B4DXG8 Q06265	O00148
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	8IJU
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity U4 SnRNA 3'-end Processing RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nuclear RNA Surveillance RNA Surveillance MRNA Catabolic Process SnRNA 3'-end Processing Nuclear MRNA Surveillance SnRNA Metabolic Process Nucleobase-containing Compound Catabolic Process SnRNA Processing RRNA Catabolic Process MRNA Metabolic Process RRNA Processing RRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Macromolecule Catabolic Process 3'-5'-RNA Exonuclease Activity RNA Metabolic Process RNA Processing RNA Binding RNA 3'-end Processing Sno(s)RNA Metabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RRNA 3'-end Processing TRNA Decay DNA Deamination Catabolic Process Nucleolus Nucleobase-containing Compound Metabolic Process CUT Catabolic Process Nucleoplasm DNA Modification Negative Regulation Of Gene Expression U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing MRNA 3'-UTR AU-rich Region Binding Nucleus Negative Regulation Of Macromolecule Biosynthetic Process	PML Body Regulation Of Ubiquitin-dependent Protein Catabolic Process Nuclear Body Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping G-rich Strand Telomeric DNA Binding Transcription Export Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process SUMO Transferase Activity RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Nuclear Export Regulation Of Proteolysis Nucleus Nuclear Chromosome Presynaptic Cytosol Postsynaptic Cytosol Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Protein Metabolic Process RNA Binding Spermidine Binding Protein Sumoylation Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly SUMO Conjugating Enzyme Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Regulation Of Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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