EXOSC9 and SKIV2L2

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
HPRD (in vivo)

		EXOSC9	SKIV2L2
Gene Name		exosome component 9	superkiller viralicidic activity 2-like 2 (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Catalytic Step 2 Spliceosome
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding AU-rich Element Binding Poly(A) RNA Binding	Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RRNA Processing Immune Response Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 MPP6 SKIV2L2 UBE2I ZDHHC17	14 interactors: DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MPHOSPH6 MPP6 PBX2 SP1 UPF2 XRN1
Entrez ID		5393	23517
HPRD ID		07315	13777
Ensembl ID		ENSG00000123737	ENSG00000039123
Uniprot IDs		B4DXG8 Q06265	P42285 Q3MHC9
PDB IDs		2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ribosome Biogenesis Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process NcRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of 5.8S RRNA Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process DNA Deamination RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process CUT Catabolic Process Catabolic Process Nuclear MRNA Surveillance Gene Expression RNA Surveillance Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis RRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Modification Nitrogen Compound Metabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Cellular Metabolic Process TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Localization SnoRNA Metabolic Process RRNA 3'-end Processing Intracellular MRNA Localization Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Processing Positive Regulation Of Cell Growth Metabolic Process Isotype Switching	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis NcRNA Metabolic Process Ribonucleoprotein Complex Biogenesis Aromatic Compound Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Metabolic Process RNA Metabolic Process Nuclear MRNA Surveillance Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Maturation Of 5.8S RRNA Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Gene Expression DNA Deamination Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Cellular Metabolic Process Histone MRNA Catabolic Process DNA Modification Positive Regulation Of Cell Growth Histone MRNA Metabolic Process Positive Regulation Of Growth Metabolic Process Sequestering Of Nodal From Receptor Via Nodal Binding Regulation Of Cell Growth Negative Regulation Of Nodal Signaling Pathway Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process
Tagcloud ?		balance compartment degradation differentiation done enriched epidermal exosome grhl3 loss maintain maintaining maintains maintenance mammalian necessary pm premature prevent prevents progenitor proliferative promotes regulating renewal reside retain transcript understood	accessed actg1 affymetrix b2m bafl bioinformatics broadly c12orf35 cbaciu de devastating dynlt1 edu filtering handle html ilkap lo pipeline qrt reasonable sals suite supplementary tardbp tm4 twelve uncc webpages
Tagcloud (Difference) ?		balance compartment degradation differentiation done enriched epidermal exosome grhl3 loss maintain maintaining maintains maintenance mammalian necessary pm premature prevent prevents progenitor proliferative promotes regulating renewal reside retain transcript understood	accessed actg1 affymetrix b2m bafl bioinformatics broadly c12orf35 cbaciu de devastating dynlt1 edu filtering handle html ilkap lo pipeline qrt reasonable sals suite supplementary tardbp tm4 twelve uncc webpages
Tagcloud (Intersection) ?