EXOSC9 and EXOSC3

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (biochemical)
HPRD (two hybrid)

		EXOSC9	EXOSC3
Gene Name		exosome component 9	exosome component 3
Image
Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding AU-rich Element Binding Poly(A) RNA Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RRNA Processing Immune Response Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Gene Expression Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 MPP6 SKIV2L2 UBE2I ZDHHC17	8 interactors: APP ATP5D CDK5RAP1 EXOSC4 EXOSC5 EXOSC8 EXOSC9 KHSRP
Entrez ID		5393	51010
HPRD ID		07315	16220
Ensembl ID		ENSG00000123737	ENSG00000107371
Uniprot IDs		B4DXG8 Q06265	Q9NQT5 Q9NYS3
PDB IDs		2NN6	2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ribosome Biogenesis Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process NcRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of 5.8S RRNA Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process DNA Deamination RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process CUT Catabolic Process Catabolic Process Nuclear MRNA Surveillance Gene Expression RNA Surveillance Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis RRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Modification Nitrogen Compound Metabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Cellular Metabolic Process TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Localization SnoRNA Metabolic Process RRNA 3'-end Processing Intracellular MRNA Localization Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Processing Positive Regulation Of Cell Growth Metabolic Process Isotype Switching	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process MRNA Metabolic Process RRNA Processing RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Aromatic Compound Catabolic Process NcRNA Metabolic Process Ribosome Biogenesis Nuclear MRNA Surveillance Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Biogenesis DNA Deamination RNA Surveillance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Catabolic Process Cellular Nitrogen Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Gene Expression DNA Modification Synaptic Growth At Neuromuscular Junction Positive Regulation Of Cell Growth Regulation Of Growth Collateral Sprouting In Absence Of Injury Cellular Metabolic Process Defense Response To Virus Nuclear Polyadenylation-dependent RRNA Catabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Growth Neuron Remodeling Regulation Of MiRNA Metabolic Process Histone MRNA Catabolic Process Response To Virus Immune System Process RRNA Catabolic Process Regulation Of Cell Growth Mitochondrial ATP Synthesis Coupled Proton Transport Maturation Of 5.8S RRNA
Tagcloud ?		balance compartment degradation differentiation done enriched epidermal exosome grhl3 loss maintain maintaining maintains maintenance mammalian necessary pm premature prevent prevents progenitor proliferative promotes regulating renewal reside retain transcript understood	aligned amenable avenues baz2a bioinformatic candidates cdk13 chem dapk1 digest dilution dst hdms hierarchical inhbe kat2b kif20b linkages noninvasive pancreatic proteomics resectable silva smc1b spag5 synapt tryptic unsupervised urgent
Tagcloud (Difference) ?		balance compartment degradation differentiation done enriched epidermal exosome grhl3 loss maintain maintaining maintains maintenance mammalian necessary pm premature prevent prevents progenitor proliferative promotes regulating renewal reside retain transcript understood	aligned amenable avenues baz2a bioinformatic candidates cdk13 chem dapk1 digest dilution dst hdms hierarchical inhbe kat2b kif20b linkages noninvasive pancreatic proteomics resectable silva smc1b spag5 synapt tryptic unsupervised urgent
Tagcloud (Intersection) ?