PMCH and PCSK2

Number of citations of the paper that reports this interaction (PubMedID 10037747)
0

Data Source:
HPRD (in vivo)

		PMCH	PCSK2
Description		pro-melanin concentrating hormone	proprotein convertase subtilisin/kexin type 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Synapse	Extracellular Region Extracellular Space Nucleoplasm Membrane Transport Vesicle Secretory Granule Cytoplasmic Vesicle Neuron Projection Intracellular Organelle Lumen
	Molecular Function	Hormone Activity Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Spermatogenesis Feeding Behavior Cell Differentiation Negative Regulation Of Synaptic Transmission, Dopaminergic	Proteolysis Nervous System Development Protein Processing Peptide Hormone Processing Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Insulin processing
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)	Biochemical measures ( 19260141) Body size at age 10 ( 32376654) Chronotype ( 30696823) Dialysis-related mortality ( 21546767) Familial lung cancer ( 29924316) Loneliness ( 27629369) Menarche (age at onset) ( 21102462 25231870) Morning person ( 30696823) Obesity-related traits ( 23251661) Preschool internalizing problems ( 24839885) Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7	3 interacting genes: IAPP PMCH SCG5
Entrez ID		5367	5126
HPRD ID		01459	01202
Ensembl ID		ENSG00000183395	ENSG00000125851
Uniprot IDs		P20382	P16519
PDB IDs		8WSS 8WST 8WWK 8WWL 8WWM 8WWN
Enriched GO Terms of Interacting Partners?		Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Protein Processing Hormone Metabolic Process Serine-type Peptidase Activity Protein Maturation Serine-type Endopeptidase Activity Peptidase Activity Endopeptidase Activity Regulation Of Hormone Levels Insulin Processing Peptide Metabolic Process Insulin Metabolic Process Neuropeptide Signaling Pathway Peptide Biosynthetic Process Regulation Of Nerve Growth Factor Production Nerve Growth Factor Production Regulation Of Biological Quality Proteolysis Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Viral Life Cycle Extracellular Space Cytokine Precursor Processing Nerve Growth Factor Binding Hydrolase Activity Endomembrane System Signal Peptide Processing Transport Vesicle Secretory Granule Golgi Lumen Secretion By Cell Peptide Binding Secretion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Trans-Golgi Network Protein Metabolic Process Signaling Cell Communication Extracellular Region Golgi Apparatus Melanin-concentrating Hormone Receptor Activity Short-day Photoperiodism Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Islet Amyloid Polypeptide Processing G Protein-coupled Receptor Signaling Pathway Neuron Projection Cytoplasmic Vesicle	G Protein-coupled Receptor Signaling Pathway Hormone Activity Feeding Behavior Neuropeptide Signaling Pathway Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Negative Regulation Of Synaptic Transmission, Dopaminergic Amylin Receptor 3 Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor Signaling Pathway Regulation Of Synaptic Transmission, Dopaminergic Calcitonin Family Receptor Signaling Pathway Extracellular Region Negative Regulation Of Amyloid Fibril Formation Cell-cell Signaling Inclusion Body Negative Regulation Of Bone Resorption Regulation Of Amyloid Fibril Formation Negative Regulation Of Bone Remodeling Positive Regulation Of CAMP/PKA Signal Transduction Signaling Bone Resorption Cell Communication Amyloid Fibril Formation Enzyme Regulator Activity Eating Behavior Negative Regulation Of Osteoclast Differentiation Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication Regulation Of Bone Remodeling Osteoclast Differentiation Regulation Of Bone Resorption Sensory Perception Of Pain Regulation Of Signaling Negative Regulation Of Synaptic Transmission Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Calcium-mediated Signaling Protein Destabilization Enzyme Inhibitor Activity
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