PMCH and MCHR2

Number of citations: 53 (PubMedID 11404457)
Data Source: HPRD (in vitro)

		PMCH	MCHR2
Name		pro-melanin concentrating hormone	melanin concentrating hormone receptor 2
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Synapse	Plasma Membrane Membrane
	Molecular Function	Hormone Activity Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding	G Protein-coupled Receptor Activity Galanin Receptor Activity
	Biological Process	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Spermatogenesis Feeding Behavior Cell Differentiation Negative Regulation Of Synaptic Transmission, Dopaminergic	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
GWAS		Adventurousness ( 30643258 ) Brain morphology (MOSTest) ( 32665545 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Height ( 19893584 ) Number of sexual partners ( 30643258 )	Adult body size ( 32376654 ) Apolipoprotein B levels ( 32203549 ) Circulating fibroblast growth factor 23 levels ( 30217807 ) Daytime nap ( 33568662 ) Erectile dysfunction ( 30297428 30583798 ) LDL cholesterol levels ( 32203549 ) Major depressive disorder ( 27479909 ) Menarche (age at onset) ( 21102462 25231870 ) Refractive error ( 32231278 ) Triglyceride levels ( 32203549 )
Interacting Genes		10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7	1 interacting genes: PMCH
Entrez ID		5367	84539
HPRD ID		01459	12088
Ensembl ID		ENSG00000183395	ENSG00000152034
Uniprot IDs		P20382	Q969V1
PDB IDs		8WSS 8WST 8WWK 8WWL 8WWM 8WWN	8WST
GO Terms Enriched among Interactors		Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Protein Processing Hormone Metabolic Process Serine-type Peptidase Activity Protein Maturation Serine-type Endopeptidase Activity Peptidase Activity Endopeptidase Activity Regulation Of Hormone Levels Insulin Processing Peptide Metabolic Process Insulin Metabolic Process Neuropeptide Signaling Pathway Peptide Biosynthetic Process Regulation Of Nerve Growth Factor Production Nerve Growth Factor Production Regulation Of Biological Quality Proteolysis Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Viral Life Cycle Extracellular Space Cytokine Precursor Processing Nerve Growth Factor Binding Hydrolase Activity Endomembrane System Signal Peptide Processing Transport Vesicle Secretory Granule Golgi Lumen Secretion By Cell Peptide Binding Secretion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Trans-Golgi Network Protein Metabolic Process Signaling Cell Communication Extracellular Region Golgi Apparatus Melanin-concentrating Hormone Receptor Activity Short-day Photoperiodism Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Islet Amyloid Polypeptide Processing G Protein-coupled Receptor Signaling Pathway Neuron Projection Cytoplasmic Vesicle	Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Negative Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Synaptic Transmission Feeding Behavior Neuropeptide Signaling Pathway Hormone Activity