PCSK2 and SCG5

Number of citations of the paper that reports this interaction (PMID 11439082)
33

Data Source:
HPRD (in vivo, in vitro)

		PCSK2	SCG5
Gene Name		proprotein convertase subtilisin/kexin type 2	secretogranin V (7B2 protein)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Membrane Transport Vesicle Dendrite Secretory Granule Lumen Perikaryon	Extracellular Region Secretory Granule
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein Complex Binding	Enzyme Inhibitor Activity Protein Binding GTP Binding Unfolded Protein Binding
	Biological Process	Proteolysis Nervous System Development Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing Cellular Protein Metabolic Process	Intracellular Protein Transport Neuropeptide Signaling Pathway Peptide Hormone Processing Negative Regulation Of Catalytic Activity Regulation Of Hormone Secretion
Pathways		Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Dialysis-related mortality ( 21546767) Menarche (age at onset) ( 21102462) Obesity-related traits ( 23251661)	Colorectal cancer ( 21761138) Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: IAPP PMCH SCG5	5 interactors: KHDRBS1 NR1H2 PCSK2 UBQLN1 UBQLN4
Entrez ID		5126	6447
HPRD ID		01202	01410
Ensembl ID		ENSG00000125851	ENSG00000166922
Uniprot IDs		P16519	C9J650 P05408
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Feeding Behavior Negative Regulation Of Bone Resorption Negative Regulation Of Bone Remodeling Behavior Negative Regulation Of Tissue Remodeling Eating Behavior Regulation Of Bone Resorption Cell-cell Signaling Peptide Hormone Processing Regulation Of Bone Remodeling Endocrine Pancreas Development G-protein Coupled Receptor Signaling Pathway	Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Enkephalin Processing Islet Amyloid Polypeptide Processing Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of RNA Export From Nucleus Regulation Of High-density Lipoprotein Particle Assembly Negative Regulation Of Pinocytosis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Cholesterol Storage Insulin Processing Positive Regulation Of Digestive System Process Protein Autoprocessing Insulin Metabolic Process Regulation Of RNA Export From Nucleus Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Translational Initiation Regulation Of Cholesterol Homeostasis Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Negative Regulation Of Lipid Storage Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Retinoic Acid Receptor Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lipid Storage Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Regulation Of Proteolysis Peptide Hormone Processing Regulation Of Cholesterol Transport Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Transport Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Endocytosis Regulation Of Cellular Response To Oxidative Stress Regulation Of Lipid Storage Positive Regulation Of Lipid Transport Positive Regulation Of Lipid Biosynthetic Process
Tagcloud ?		2kd abcc8 antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis peg3 producing proglucagon protected recognize reserved rights scg2 specificities
Tagcloud (Difference) ?		2kd abcc8 antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis peg3 producing proglucagon protected recognize reserved rights scg2 specificities
Tagcloud (Intersection) ?