PMCH and PCSK7

Number of citations of the paper that reports this interaction (PMID 10037747)
6

Data Source:
HPRD (in vivo)

		PMCH	PCSK7
Gene Name		pro-melanin-concentrating hormone	proprotein convertase subtilisin/kexin type 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus	Integral Component Of Golgi Membrane
	Molecular Function	Melanin-concentrating Hormone Activity	Serine-type Endopeptidase Activity Peptidase Activity
	Biological Process	Neuropeptide Signaling Pathway Synaptic Transmission Multicellular Organismal Development Spermatogenesis Feeding Behavior Cell Differentiation	Proteolysis Protein Processing Peptide Hormone Processing
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Height ( 19893584)	Cardiovascular disease risk factors ( 21943158) Iron status biomarkers ( 21149283)
Protein-Protein Interactions		10 interactors: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7	6 interactors: CSDE1 HNRNPD HSPA5 PABPC1 PMCH SYNCRIP
Entrez ID		5367	9159
HPRD ID		01459	05339
Ensembl ID		ENSG00000183395
Uniprot IDs		P20382	Q16549
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptide Hormone Processing Peptide Metabolic Process Hormone Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Nerve Growth Factor Processing Nerve Growth Factor Production Peptide Biosynthetic Process Proteolysis Insulin Processing Insulin Metabolic Process Neuropeptide Signaling Pathway Signal Peptide Processing Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Signaling Cell Communication Cell-cell Signaling Enkephalin Processing Islet Amyloid Polypeptide Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Renin Secretion Into Blood Stream Feeding Behavior Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure G-protein Coupled Receptor Signaling Pathway Secretion By Cell Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Cellular Response To Growth Factor Stimulus Signal Transduction Zygotic Determination Of Anterior/posterior Axis, Embryo Response To Growth Factor G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Secretion Positive Regulation Of Appetite Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Blood Pressure Viral Life Cycle Protein Autoprocessing Adult Feeding Behavior Viral Protein Processing Anterior/posterior Pattern Specification Enzyme Linked Receptor Protein Signaling Pathway	Regulation Of MRNA Stability Regulation Of RNA Stability MRNA Metabolic Process RNA Catabolic Process MRNA Stabilization MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecule Catabolic Process Regulation Of Translation RNA Splicing MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Translation Regulation Of Protein Folding In Endoplasmic Reticulum RNA Processing Catabolic Process Cerebellum Structural Organization Nuclear-transcribed MRNA Catabolic Process Regulation Of Cellular Protein Metabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Protein Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization Circadian Regulation Of Translation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process ER Overload Response Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Regulation Of MRNA 3'-end Processing Cellular Response To Antibiotic Anatomical Structure Arrangement Positive Regulation Of MRNA Catabolic Process Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Polyadenylation Cellular Response To Cytokine Stimulus Cerebellar Purkinje Cell Layer Development RNA Polyadenylation Substantia Nigra Development ER-associated Ubiquitin-dependent Protein Catabolic Process Toxin Transport Cellular Response To Interleukin-4 Response To Cytokine
Tagcloud ?			aric atherogenic atherosclerosis biracial chd close communities confidence dense discovered hazard hazards homogeneous incident insights interval ldl lipid lipoprotein loci locus lowest mellitus newly proportional quartile sdldl traits variants
Tagcloud (Difference) ?			aric atherogenic atherosclerosis biracial chd close communities confidence dense discovered hazard hazards homogeneous incident insights interval ldl lipid lipoprotein loci locus lowest mellitus newly proportional quartile sdldl traits variants
Tagcloud (Intersection) ?