PMCH and PCSK6

Number of citations of the paper that reports this interaction (PMID 10037747)
6

Data Source:
HPRD (in vivo, in vitro)

		PMCH	PCSK6
Gene Name		pro-melanin-concentrating hormone	proprotein convertase subtilisin/kexin type 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus	Extracellular Space Endoplasmic Reticulum Golgi Lumen Cell Surface Membrane Extracellular Matrix
	Molecular Function	Melanin-concentrating Hormone Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Heparin Binding Nerve Growth Factor Binding
	Biological Process	Neuropeptide Signaling Pathway Synaptic Transmission Multicellular Organismal Development Spermatogenesis Feeding Behavior Cell Differentiation	Proteolysis Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Processing Nerve Growth Factor Production Secretion By Cell Neurotrophin TRK Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Signalling by NGF NGF processing Signaling by NODAL
Drugs
Diseases
GWAS		Height ( 19893584)	Handedness in dyslexia ( 21051773)
Protein-Protein Interactions		10 interactors: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7	4 interactors: CACNA1A FLG PMCH RCN3
Entrez ID		5367	5046
HPRD ID		01459	01329
Ensembl ID		ENSG00000183395	ENSG00000140479
Uniprot IDs		P20382	P29122
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptide Hormone Processing Peptide Metabolic Process Hormone Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Nerve Growth Factor Processing Nerve Growth Factor Production Peptide Biosynthetic Process Proteolysis Insulin Processing Insulin Metabolic Process Neuropeptide Signaling Pathway Signal Peptide Processing Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Signaling Cell Communication Cell-cell Signaling Enkephalin Processing Islet Amyloid Polypeptide Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Renin Secretion Into Blood Stream Feeding Behavior Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure G-protein Coupled Receptor Signaling Pathway Secretion By Cell Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Cellular Response To Growth Factor Stimulus Signal Transduction Zygotic Determination Of Anterior/posterior Axis, Embryo Response To Growth Factor G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Secretion Positive Regulation Of Appetite Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Blood Pressure Viral Life Cycle Protein Autoprocessing Adult Feeding Behavior Viral Protein Processing Anterior/posterior Pattern Specification Enzyme Linked Receptor Protein Signaling Pathway	Cell-cell Signaling Cerebellar Molecular Layer Development Vestibular Nucleus Development Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Regulation Of Lateral Mesodermal Cell Fate Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Regulation Of Acetylcholine Secretion, Neurotransmission Orbitofrontal Cortex Development Rhythmic Synaptic Transmission Regulation Of Neuron Projection Development Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Outer Ear Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Regulation Of Cell Projection Organization Negative Regulation Of Hormone Biosynthetic Process Pons Development Regulation Of Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Cerebellar Purkinje Cell Differentiation Mesenchymal-epithelial Cell Signaling Behavior Forebrain Neuroblast Division Regulation Of Branching Involved In Salivary Gland Morphogenesis Neuron Projection Morphogenesis Establishment Of Skin Barrier Cerebellar Purkinje Cell Layer Morphogenesis Auditory Receptor Cell Development Lung-associated Mesenchyme Development Cell Surface Receptor Signaling Pathway Regulation Of Cell Fate Specification Regulation Of Water Loss Via Skin Regulation Of Neurogenesis Reflex Cell Morphogenesis Involved In Differentiation Behavioral Response To Pain Neuromuscular Synaptic Transmission Cell Differentiation Brain Development Regulation Of Hormone Biosynthetic Process Paraxial Mesoderm Development Middle Ear Morphogenesis
Tagcloud ?			absent astrocytic cadherin candidate cdh11 convertase endocytosis functionally glioblastoma glioblastomas glioma gliomas immunoreactivity infiltrating infiltration infiltrative invasion kexin microdissected ontology proprotein rich sh3 sh3gl3 subtilisin tumour validate validated zone
Tagcloud (Difference) ?			absent astrocytic cadherin candidate cdh11 convertase endocytosis functionally glioblastoma glioblastomas glioma gliomas immunoreactivity infiltrating infiltration infiltrative invasion kexin microdissected ontology proprotein rich sh3 sh3gl3 subtilisin tumour validate validated zone
Tagcloud (Intersection) ?