PMCH and PCSK5

Number of citations of the paper that reports this interaction (PMID 10037747)
6

Data Source:
HPRD (in vivo)

		PMCH	PCSK5
Gene Name		pro-melanin-concentrating hormone	proprotein convertase subtilisin/kexin type 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus	Extracellular Space Golgi Apparatus Golgi Lumen Integral Component Of Membrane Secretory Granule
	Molecular Function	Melanin-concentrating Hormone Activity	Serine-type Endopeptidase Activity Peptidase Activity Peptide Binding
	Biological Process	Neuropeptide Signaling Pathway Synaptic Transmission Multicellular Organismal Development Spermatogenesis Feeding Behavior Cell Differentiation	Kidney Development Renin Secretion Into Blood Stream Signal Peptide Processing Proteolysis Cell-cell Signaling Heart Development Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Nerve Growth Factor Processing Limb Morphogenesis Cytokine Biosynthetic Process Peptide Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Embryonic Digestive Tract Development Embryonic Skeletal System Development
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Signalling by NGF NGF processing
Drugs
Diseases
GWAS		Height ( 19893584)	Amyotrophic lateral sclerosis (age of onset) ( 22959728) Height ( 20881960 23563607) Metabolite levels (5-HIAA) ( 23319000) Response to fenofibrate (adiponectin levels) ( 23149075) Total ventricular volume ( 21116278)
Protein-Protein Interactions		10 interactors: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7	20 interactors: AMH APPBP2 ATN1 CACNA1A GLRX3 HOXA1 ITGA6 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP4-12 KRTAP5-9 LCE3C MEOX2 NOTCH2NL NUFIP2 PMCH PTPRM REN STK16
Entrez ID		5367	5125
HPRD ID		01459	08985
Ensembl ID		ENSG00000183395	ENSG00000099139
Uniprot IDs		P20382	Q92824
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptide Hormone Processing Peptide Metabolic Process Hormone Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Nerve Growth Factor Processing Nerve Growth Factor Production Peptide Biosynthetic Process Proteolysis Insulin Processing Insulin Metabolic Process Neuropeptide Signaling Pathway Signal Peptide Processing Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Signaling Cell Communication Cell-cell Signaling Enkephalin Processing Islet Amyloid Polypeptide Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Renin Secretion Into Blood Stream Feeding Behavior Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure G-protein Coupled Receptor Signaling Pathway Secretion By Cell Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Cellular Response To Growth Factor Stimulus Signal Transduction Zygotic Determination Of Anterior/posterior Axis, Embryo Response To Growth Factor G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Secretion Positive Regulation Of Appetite Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Blood Pressure Viral Life Cycle Protein Autoprocessing Adult Feeding Behavior Viral Protein Processing Anterior/posterior Pattern Specification Enzyme Linked Receptor Protein Signaling Pathway	Developmental Process Multicellular Organismal Development Pons Development Cell Differentiation Anatomical Structure Development Organ Development System Development Tissue Development Behavior Neural Nucleus Development Optokinetic Behavior Cerebellar Molecular Layer Development Abducens Nerve Formation Neuron Death Vestibular Nucleus Development Facial Nucleus Development Preantral Ovarian Follicle Growth Urogenital System Development Feeding Behavior Positive Regulation Of Gene Expression Rhombomere 4 Development Cerebellum Maturation Semicircular Canal Formation Musculoskeletal Movement, Spinal Reflex Action Anatomical Structure Morphogenesis Rhombomere 3 Development Rhombomere 5 Development Gamma-aminobutyric Acid Secretion Renin-angiotensin Regulation Of Aldosterone Production Metencephalon Development Neuromuscular Process Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Response To Drug Rhythmic Synaptic Transmission Somite Specification Ectodermal Cell Differentiation Cell Development Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Oogenesis Stage Cell Projection Organization Drinking Behavior Gonadal Mesoderm Development Response To CGMP Mullerian Duct Regression Hindbrain Development Cell Morphogenesis Involved In Neuron Differentiation Calcium Ion-dependent Exocytosis Of Neurotransmitter
Tagcloud ?			angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1
Tagcloud (Difference) ?			angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1
Tagcloud (Intersection) ?