PCSK2 and PMCH

Number of citations: 0 (PubMedID 10037747)
Data Source: HPRD (in vivo)

		PCSK2	PMCH
Name		proprotein convertase subtilisin/kexin type 2	pro-melanin concentrating hormone
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Membrane Transport Vesicle Secretory Granule Cytoplasmic Vesicle Neuron Projection Intracellular Organelle Lumen	Extracellular Region Nucleus Synapse
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Hormone Activity Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding
	Biological Process	Proteolysis Nervous System Development Protein Processing Peptide Hormone Processing Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Spermatogenesis Feeding Behavior Cell Differentiation Negative Regulation Of Synaptic Transmission, Dopaminergic
Pathways		Insulin processing	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
GWAS		Biochemical measures ( 19260141 ) Body size at age 10 ( 32376654 ) Chronotype ( 30696823 ) Dialysis-related mortality ( 21546767 ) Familial lung cancer ( 29924316 ) Loneliness ( 27629369 ) Menarche (age at onset) ( 21102462 25231870 ) Morning person ( 30696823 ) Obesity-related traits ( 23251661 ) Preschool internalizing problems ( 24839885 ) Response to fenofibrate (triglyceride levels) ( 27002377 )	Adventurousness ( 30643258 ) Brain morphology (MOSTest) ( 32665545 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Height ( 19893584 ) Number of sexual partners ( 30643258 )
Interacting Genes		3 interacting genes: IAPP PMCH SCG5	10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		5126	5367
HPRD ID		01202	01459
Ensembl ID		ENSG00000125851	ENSG00000183395
Uniprot IDs		P16519	P20382
PDB IDs		Not available	8WSS 8WST 8WWK 8WWL 8WWM 8WWN
GO Terms Enriched among Interactors		G Protein-coupled Receptor Signaling Pathway Hormone Activity Feeding Behavior Neuropeptide Signaling Pathway Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Negative Regulation Of Synaptic Transmission, Dopaminergic Amylin Receptor 3 Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor Signaling Pathway Regulation Of Synaptic Transmission, Dopaminergic Calcitonin Family Receptor Signaling Pathway Extracellular Region Negative Regulation Of Amyloid Fibril Formation Cell-cell Signaling Inclusion Body Negative Regulation Of Bone Resorption Regulation Of Amyloid Fibril Formation Negative Regulation Of Bone Remodeling Positive Regulation Of CAMP/PKA Signal Transduction Signaling Bone Resorption Cell Communication Amyloid Fibril Formation Enzyme Regulator Activity Eating Behavior Negative Regulation Of Osteoclast Differentiation Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication Regulation Of Bone Remodeling Osteoclast Differentiation Regulation Of Bone Resorption Sensory Perception Of Pain Regulation Of Signaling Negative Regulation Of Synaptic Transmission Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Calcium-mediated Signaling Protein Destabilization Enzyme Inhibitor Activity	Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Protein Processing Hormone Metabolic Process Serine-type Peptidase Activity Protein Maturation Serine-type Endopeptidase Activity Peptidase Activity Endopeptidase Activity Regulation Of Hormone Levels Insulin Processing Peptide Metabolic Process Insulin Metabolic Process Neuropeptide Signaling Pathway Peptide Biosynthetic Process Regulation Of Nerve Growth Factor Production Nerve Growth Factor Production Regulation Of Biological Quality Proteolysis Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Viral Life Cycle Extracellular Space Cytokine Precursor Processing Nerve Growth Factor Binding Hydrolase Activity Endomembrane System Signal Peptide Processing Transport Vesicle Secretory Granule Golgi Lumen Secretion By Cell Peptide Binding Secretion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Trans-Golgi Network Protein Metabolic Process Signaling Cell Communication Extracellular Region Golgi Apparatus Melanin-concentrating Hormone Receptor Activity Short-day Photoperiodism Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Islet Amyloid Polypeptide Processing G Protein-coupled Receptor Signaling Pathway Neuron Projection Cytoplasmic Vesicle