PCSK2 and PMCH

Number of citations of the paper that reports this interaction (PMID 10037747)
6

Data Source:
HPRD (in vivo)

		PCSK2	PMCH
Gene Name		proprotein convertase subtilisin/kexin type 2	pro-melanin-concentrating hormone
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Membrane Transport Vesicle Dendrite Secretory Granule Lumen Perikaryon	Extracellular Region Nucleus
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein Complex Binding	Melanin-concentrating Hormone Activity
	Biological Process	Proteolysis Nervous System Development Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing Cellular Protein Metabolic Process	Neuropeptide Signaling Pathway Synaptic Transmission Multicellular Organismal Development Spermatogenesis Feeding Behavior Cell Differentiation
Pathways		Peptide hormone metabolism Insulin processing	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Dialysis-related mortality ( 21546767) Menarche (age at onset) ( 21102462) Obesity-related traits ( 23251661)	Height ( 19893584)
Protein-Protein Interactions		3 interactors: IAPP PMCH SCG5	10 interactors: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		5126	5367
HPRD ID		01202	01459
Ensembl ID		ENSG00000125851	ENSG00000183395
Uniprot IDs		P16519	P20382
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Feeding Behavior Negative Regulation Of Bone Resorption Negative Regulation Of Bone Remodeling Behavior Negative Regulation Of Tissue Remodeling Eating Behavior Regulation Of Bone Resorption Cell-cell Signaling Peptide Hormone Processing Regulation Of Bone Remodeling Endocrine Pancreas Development G-protein Coupled Receptor Signaling Pathway	Peptide Hormone Processing Peptide Metabolic Process Hormone Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Nerve Growth Factor Processing Nerve Growth Factor Production Peptide Biosynthetic Process Proteolysis Insulin Processing Insulin Metabolic Process Neuropeptide Signaling Pathway Signal Peptide Processing Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Signaling Cell Communication Cell-cell Signaling Enkephalin Processing Islet Amyloid Polypeptide Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Renin Secretion Into Blood Stream Feeding Behavior Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure G-protein Coupled Receptor Signaling Pathway Secretion By Cell Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Cellular Response To Growth Factor Stimulus Signal Transduction Zygotic Determination Of Anterior/posterior Axis, Embryo Response To Growth Factor G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Secretion Positive Regulation Of Appetite Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Blood Pressure Viral Life Cycle Protein Autoprocessing Adult Feeding Behavior Viral Protein Processing Anterior/posterior Pattern Specification Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		2kd abcc8 antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis peg3 producing proglucagon protected recognize reserved rights scg2 specificities
Tagcloud (Difference) ?		2kd abcc8 antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis peg3 producing proglucagon protected recognize reserved rights scg2 specificities
Tagcloud (Intersection) ?