PCSK2 and IAPP

Number of citations of the paper that reports this interaction (PubMedID 8557106)
0

Data Source:
HPRD (in vitro, in vivo)

		PCSK2	IAPP
Description		proprotein convertase subtilisin/kexin type 2	islet amyloid polypeptide
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Membrane Transport Vesicle Secretory Granule Cytoplasmic Vesicle Neuron Projection Intracellular Organelle Lumen	Extracellular Region Extracellular Space Inclusion Body Neuronal Cell Body
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Lipid Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Proteolysis Nervous System Development Protein Processing Peptide Hormone Processing Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing	Apoptotic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Sensory Perception Of Pain Osteoclast Differentiation Negative Regulation Of Protein-containing Complex Assembly Protein Destabilization Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Bone Resorption Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Calcium-mediated Signaling Protein Homooligomerization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor 3 Signaling Pathway Negative Regulation Of Amyloid Fibril Formation Amyloid Fibril Formation
Pathways		Insulin processing	Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors Amyloid fiber formation
Drugs			Copper
Diseases
GWAS		Biochemical measures ( 19260141) Body size at age 10 ( 32376654) Chronotype ( 30696823) Dialysis-related mortality ( 21546767) Familial lung cancer ( 29924316) Loneliness ( 27629369) Menarche (age at onset) ( 21102462 25231870) Morning person ( 30696823) Obesity-related traits ( 23251661) Preschool internalizing problems ( 24839885) Response to fenofibrate (triglyceride levels) ( 27002377)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		3 interacting genes: IAPP PMCH SCG5	6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2
Entrez ID		5126	3375
HPRD ID		01202	01005
Ensembl ID		ENSG00000125851	ENSG00000121351
Uniprot IDs		P16519	P10997
PDB IDs			1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ 6UCJ 6UCK 6VW2 6Y1A 6ZRF 6ZRQ 6ZRR 7BG0 7M61 7M62 7M64 7M65 7YKW 7YL0 7YL3 7YL7 8AWT 8AZ0 8AZ1 8AZ2 8AZ3 8AZ4 8AZ5 8AZ6 8AZ7 8F0J 8F0K 8F2A 8F2B 8R4I 8YG2 9GZ6 9GZP 9GZS 9GZT 9GZW 9GZX 9GZY
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Hormone Activity Feeding Behavior Neuropeptide Signaling Pathway Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Negative Regulation Of Synaptic Transmission, Dopaminergic Amylin Receptor 3 Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor Signaling Pathway Regulation Of Synaptic Transmission, Dopaminergic Calcitonin Family Receptor Signaling Pathway Extracellular Region Negative Regulation Of Amyloid Fibril Formation Cell-cell Signaling Inclusion Body Negative Regulation Of Bone Resorption Regulation Of Amyloid Fibril Formation Negative Regulation Of Bone Remodeling Positive Regulation Of CAMP/PKA Signal Transduction Signaling Bone Resorption Cell Communication Amyloid Fibril Formation Enzyme Regulator Activity Eating Behavior Negative Regulation Of Osteoclast Differentiation Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication Regulation Of Bone Remodeling Osteoclast Differentiation Regulation Of Bone Resorption Sensory Perception Of Pain Regulation Of Signaling Negative Regulation Of Synaptic Transmission Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Calcium-mediated Signaling Protein Destabilization Enzyme Inhibitor Activity	Insulin Processing Amylin Receptor Signaling Pathway Calcitonin Family Receptor Signaling Pathway Insulin Metabolic Process Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Coreceptor Activity Cellular Response To Acadesine Islet Amyloid Polypeptide Processing Receptor Internalization Calcitonin Gene-related Peptide Binding Endopeptidase Activity Regulation Of Hormone Levels Transport Vesicle Secretory Granule Response To Chlorate Enkephalin Processing Adrenomedullin Binding CGRP Receptor Complex Serine-type Peptidase Activity Response To Hormone Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Proliferation Serine-type Endopeptidase Activity Adrenomedullin Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Basement Membrane Assembly Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Receptor 2 Signaling Pathway Adrenomedullin Receptor Complex Amylin Receptor 1 Signaling Pathway Positive Regulation Of Protein Glycosylation Amylin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Receptor-mediated Endocytosis Hormone Metabolic Process Protein Processing Protein Localization To Plasma Membrane Adrenomedullin Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Receptor Complex Glucose Mediated Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Transdifferentiation Response To Iron(II) Ion Regulation Of Protein Glycosylation Protein Localization To Cell Periphery Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Carbohydrate Mediated Signaling Calcium Ion Transport
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