PMCH and MCHR1

Number of citations of the paper that reports this interaction (PMID 11839762)
2

Data Source:
HPRD (in vitro)

		PMCH	MCHR1
Gene Name		pro-melanin-concentrating hormone	melanin-concentrating hormone receptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus	Plasma Membrane Integral Component Of Plasma Membrane Nonmotile Primary Cilium Ciliary Membrane
	Molecular Function	Melanin-concentrating Hormone Activity	G-protein Coupled Receptor Activity Protein C-terminus Binding Neuropeptide Receptor Activity Melanin-concentrating Hormone Receptor Activity Hormone Binding
	Biological Process	Neuropeptide Signaling Pathway Synaptic Transmission Multicellular Organismal Development Spermatogenesis Feeding Behavior Cell Differentiation	Generation Of Precursor Metabolites And Energy G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Feeding Behavior Positive Regulation Of Calcium Ion Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Class A/1 (Rhodopsin-like receptors) Assembly of the primary cilium Metabolic disorders of biological oxidation enzymes GPCR ligand binding BBSome-mediated cargo-targeting to cilium G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events
Drugs
Diseases
GWAS		Height ( 19893584)
Protein-Protein Interactions		10 interactors: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7	2 interactors: PMCH ZMYND19
Entrez ID		5367	2847
HPRD ID		01459	11874
Ensembl ID		ENSG00000183395	ENSG00000128285
Uniprot IDs		P20382	A6ZJ87 Q5IFI4 Q99705
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptide Hormone Processing Peptide Metabolic Process Hormone Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Nerve Growth Factor Processing Nerve Growth Factor Production Peptide Biosynthetic Process Proteolysis Insulin Processing Insulin Metabolic Process Neuropeptide Signaling Pathway Signal Peptide Processing Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Signaling Cell Communication Cell-cell Signaling Enkephalin Processing Islet Amyloid Polypeptide Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Renin Secretion Into Blood Stream Feeding Behavior Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure G-protein Coupled Receptor Signaling Pathway Secretion By Cell Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Cellular Response To Growth Factor Stimulus Signal Transduction Zygotic Determination Of Anterior/posterior Axis, Embryo Response To Growth Factor G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Secretion Positive Regulation Of Appetite Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Blood Pressure Viral Life Cycle Protein Autoprocessing Adult Feeding Behavior Viral Protein Processing Anterior/posterior Pattern Specification Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?			ac3 adenylyl alms1 alstrom anomalies antennae appetite arl13b bardet bbs biedl cilia ciliary ciliopathies ciliopathy coinciding develops displaying etiologies foz hyperphagia localizes maintains morbid organelle parallels satiety sstr3 truncating
Tagcloud (Difference) ?			ac3 adenylyl alms1 alstrom anomalies antennae appetite arl13b bardet bbs biedl cilia ciliary ciliopathies ciliopathy coinciding develops displaying etiologies foz hyperphagia localizes maintains morbid organelle parallels satiety sstr3 truncating
Tagcloud (Intersection) ?