USP16 and DNM1L

Number of citations of the paper that reports this interaction (PubMedID 37488647)
36

Data Source:
BioGRID (pull down)

		USP16	DNM1L
Description		ubiquitin specific peptidase 16	dynamin 1 like
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Brush Border Clathrin-coated Pit Endomembrane System Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Mitochondrion-derived Vesicle
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Ribosomal Small Subunit Binding Ubiquitin Binding Metal Ion Binding Histone H2A Deubiquitinase Activity	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Microtubule Binding Lipid Binding Hydrolase Activity GTP-dependent Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis DNA Damage Response Regulation Of Gene Expression Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Positive Regulation Of Ribosome Biogenesis Mitotic Nuclear Division	Mitochondrial Fission Calcium Ion Transport Endocytosis Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Gene Expression Regulation Of Mitochondrion Organization Programmed Cell Death Peroxisome Fission Mitochondrial Fragmentation Involved In Apoptotic Process Intracellular Distribution Of Mitochondria Rhythmic Process Positive Regulation Of Protein Secretion Protein Complex Oligomerization Heart Contraction Protein Localization To Mitochondrion Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Mitochondrial Fission Mitochondrial Membrane Fission Mitocytosis Regulation Of Peroxisome Organization Regulation Of Mitophagy Positive Regulation Of Secretion By Cell Regulation Of ATP Metabolic Process
Pathways		Ub-specific processing proteases	Apoptotic execution phase
Drugs
Diseases
GWAS			Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		23 interacting genes: CALM1 CDK1 DNM1L EXOSC10 FAU FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4C16 ISG15 LINC02381 PAX6 PLK1 PTOV1 SATB1 TTK UBC UBD XRN2 ZEB2	23 interacting genes: CAP2 FILNC1 FIS1 FZR1 GSK3B MAGEA1 MAGEA3 MAP3K10 MFF MIEF1 MIEF2 MUL1 PINK1 PRKN RRM2 SCG3 SENP3 SH3GL1 SIRT3 SUMO2 USP16 VIM ZBTB24
Entrez ID		10600	10059
HPRD ID		06881	04833
Ensembl ID		ENSG00000156256	ENSG00000087470
Uniprot IDs		Q9Y5T5	B4DYR6 O00429
PDB IDs		2I50 8WG5	3W6N 3W6O 3W6P 4BEJ 4H1U 4H1V 5WP9 8T1H
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome Chromatin Remodeling Protein Tag Activity Chromosome Regulation Of Chromosome Organization Chromatin Organization Post-translational Protein Modification Protein Ubiquitination Protein Localization To Organelle Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Heterodimerization Activity Female Meiosis Chromosome Segregation Regulation Of Sister Chromatid Segregation Spindle Microtubule Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Segregation G2/M Transition Of Mitotic Cell Cycle Heterochromatin Formation Protein Localization To Chromatin Nucleoplasm Nucleus Mitotic Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Mitotic Nuclear Membrane Disassembly Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Telomerase RNA Localization To Cajal Body Protein Localization To Kinetochore Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Meiotic Chromosome Segregation Nuclear Membrane Disassembly Negative Regulation Of Biosynthetic Process Membrane Disassembly Negative Regulation Of Chromosome Organization CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Gene Expression Positive Regulation Of Protein Localization To Nucleus	Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Organization Mitochondrial Fission Mitochondrion Organization Mitochondrial Outer Membrane Peroxisome Positive Regulation Of Organelle Organization Positive Regulation Of Type 2 Mitophagy Regulation Of Mitochondrial Fusion Cellular Response To Toxic Substance Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitophagy Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Modification Process Regulation Of Proteolysis Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Mitochondrial Fusion Response To Hydrogen Sulfide Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Modification Process Lewy Body Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitophagy Negative Regulation Of Mitochondrial Fusion Ubiquitin Protein Ligase Binding Regulation Of Autophagy Of Mitochondrion Regulation Of Establishment Of Protein Localization Positive Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Positive Regulation Of Catabolic Process Mitochondrial Fragmentation Involved In Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Post-translational Protein Modification Regulation Of Protein Metabolic Process
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