USP16 and HIST2H2AA3

Number of citations of the paper that reports this interaction (PMID 17914355)
60

Data Source:
BioGRID (enzymatic study)

		USP16	HIST2H2AA3
Gene Name		ubiquitin specific peptidase 16	histone cluster 2, H2aa3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleosome Nucleus Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Zinc Ion Binding Histone Binding Ubiquitin Binding	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Cycle Mitotic Nuclear Division Histone Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Elongation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Homotetramerization Cell Division Regulation Of Proteasomal Protein Catabolic Process Histone H2A K63-linked Deubiquitination	Biological_process
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CALM1 CDK1 EXOSC10 FBXO11 HIST1H2AB HIST1H2BB HIST2H2AA3 HIST2H2AC HIST4H4 PTOV1 UBC UBD	16 interactors: APP BAP1 BMI1 DNAJC2 IL33 MSL2 NOC2L PARP1 PRMT6 RCC1 RNF2 RNF20 TBL1X UBE2H USP16 USP21
Entrez ID		10600	8337
HPRD ID		06881	08851
Ensembl ID		ENSG00000156256
Uniprot IDs		Q9Y5T5	Q6FI13
PDB IDs		2I50
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process DNA Packaging Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Catabolic Process Response To Amine Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity DNA Conformation Change Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Glycogen Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle MyD88-independent Toll-like Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 3 Signaling Pathway Pronuclear Fusion Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription MyD88-dependent Toll-like Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Polysaccharide Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Vascular Endothelial Growth Factor Receptor Signaling Pathway Mitotic DNA Integrity Checkpoint Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway	Chromosome Organization Chromatin Organization Chromatin Modification Histone Modification Organelle Organization Histone Ubiquitination Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Histone Deubiquitination Histone Monoubiquitination Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone H2A-K119 Monoubiquitination Protein Metabolic Process Protein Catabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Protein Monoubiquitination Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Macromolecule Catabolic Process
Tagcloud ?		critically defective deubiquitinase deubiquitinates deubiquitination enter example h2a h2b hela hox identifies laevis ligase mitosis mitotic modifications notably nucleosomal owing posterior predominately prefers prerequisite segregation slow ubiquitination ubp xenopus
Tagcloud (Difference) ?		critically defective deubiquitinase deubiquitinates deubiquitination enter example h2a h2b hela hox identifies laevis ligase mitosis mitotic modifications notably nucleosomal owing posterior predominately prefers prerequisite segregation slow ubiquitination ubp xenopus
Tagcloud (Intersection) ?