USP16 and FBXO11

Number of citations of the paper that reports this interaction (PubMedID 21090589)
41

Data Source:
BioGRID (unspecified method)

		USP16	FBXO11
Description		ubiquitin specific peptidase 16	F-box protein 11
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Ribosomal Small Subunit Binding Ubiquitin Binding Metal Ion Binding Histone H2A Deubiquitinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-arginine N-methyltransferase Activity Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis DNA Damage Response Regulation Of Gene Expression Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Positive Regulation Of Ribosome Biogenesis Mitotic Nuclear Division	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Sound Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Ub-specific processing proteases	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Asthma ( 27611488) Chronotype ( 30696823) Cortical surface area ( 32963231) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Macular thickness ( 30535121) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 23894747)
Interacting Genes		23 interacting genes: CALM1 CDK1 DNM1L EXOSC10 FAU FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4C16 ISG15 LINC02381 PAX6 PLK1 PTOV1 SATB1 TTK UBC UBD XRN2 ZEB2	8 interacting genes: BAHD1 BCL6 CFTR DSCR9 HDAC6 HNRNPA2B1 TP53 USP16
Entrez ID		10600	80204
HPRD ID		06881	06985
Ensembl ID		ENSG00000156256	ENSG00000138081
Uniprot IDs		Q9Y5T5	A0A804HK63 Q86XK2
PDB IDs		2I50 8WG5	5VMD
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome Chromatin Remodeling Protein Tag Activity Chromosome Regulation Of Chromosome Organization Chromatin Organization Post-translational Protein Modification Protein Ubiquitination Protein Localization To Organelle Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Heterodimerization Activity Female Meiosis Chromosome Segregation Regulation Of Sister Chromatid Segregation Spindle Microtubule Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Segregation G2/M Transition Of Mitotic Cell Cycle Heterochromatin Formation Protein Localization To Chromatin Nucleoplasm Nucleus Mitotic Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Mitotic Nuclear Membrane Disassembly Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Telomerase RNA Localization To Cajal Body Protein Localization To Kinetochore Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Meiotic Chromosome Segregation Nuclear Membrane Disassembly Negative Regulation Of Biosynthetic Process Membrane Disassembly Negative Regulation Of Chromosome Organization CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Gene Expression Positive Regulation Of Protein Localization To Nucleus	Chromatin Remodeling Epigenetic Regulation Of Gene Expression Chromatin Organization Negative Regulation Of Cell Growth Negative Regulation Of DNA Replication Negative Regulation Of Gene Expression, Epigenetic Replication Fork 14-3-3 Protein Binding Negative Regulation Of Growth Negative Regulation Of Macroautophagy Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Senescence Regulation Of Lymphocyte Apoptotic Process Cellular Response To Stress Transcription Corepressor Binding Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Cell Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Molecular Condensate Scaffold Activity Regulation Of Mitophagy Negative Regulation Of Helicase Activity Regulation Of Autophagy Of Mitochondrion Negative Regulation Of G1 To G0 Transition Mitophagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Ribosome Biogenesis T Cell Activation Involved In Immune Response Autophagy Of Mitochondrion Regulation Of DNA Metabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Lymphocyte Activation Involved In Immune Response Negative Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle DNA Replication Regulation Of DNA Replication Negative Regulation Of Mast Cell Cytokine Production Isotype Switching To IgE Isotypes Mononuclear Cell Proliferation Regulation Of Cell Growth Chromatin Binding Lymphocyte Proliferation Negative Regulation Of Plasma Cell Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein-folding Chaperone Binding Enzyme Binding Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport
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