USP16 and FBXO11

Number of citations of the paper that reports this interaction (PMID 21090589)
3

Data Source:
BioGRID (unspecified method)

		USP16	FBXO11
Gene Name		ubiquitin specific peptidase 16	F-box protein 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Ubiquitin Ligase Complex Nucleus Chromosome Nucleolus Cytoplasm
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Zinc Ion Binding Histone Binding Ubiquitin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-arginine N-methyltransferase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Cycle Mitotic Nuclear Division Histone Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Elongation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Homotetramerization Cell Division Regulation Of Proteasomal Protein Catabolic Process Histone H2A K63-linked Deubiquitination	Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Sound Protein Ubiquitination Peptidyl-arginine N-methylation
Pathways
Drugs
Diseases
GWAS			Schizophrenia ( 23894747)
Protein-Protein Interactions		12 interactors: CALM1 CDK1 EXOSC10 FBXO11 HIST1H2AB HIST1H2BB HIST2H2AA3 HIST2H2AC HIST4H4 PTOV1 UBC UBD	5 interactors: BCL6 HDAC6 SKP1 TP53 USP16
Entrez ID		10600	80204
HPRD ID		06881	06985
Ensembl ID		ENSG00000156256	ENSG00000138081
Uniprot IDs		Q9Y5T5	Q86XK2
PDB IDs		2I50
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process DNA Packaging Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Catabolic Process Response To Amine Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity DNA Conformation Change Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Glycogen Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle MyD88-independent Toll-like Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 3 Signaling Pathway Pronuclear Fusion Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription MyD88-dependent Toll-like Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Polysaccharide Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Vascular Endothelial Growth Factor Receptor Signaling Pathway Mitotic DNA Integrity Checkpoint Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway	Chromatin Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Histone Deacetylation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Deacetylation Protein Import Into Nucleus, Translocation Positive Regulation Of Cellular Metabolic Process Chromosome Organization Regulation Of Histone Deacetylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Deacetylation Histone Modification Organelle Organization Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Histone Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Programmed Cell Death Chromatin Modification Negative Regulation Of DNA Metabolic Process Protein Catabolic Process Positive Regulation Of Cell Death B Cell Differentiation Protein Tetramerization Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Hsp90 Deacetylation Regulation Of Proteolysis Mitotic Cell Cycle Process Protein Import Into Nucleus Nuclear Import Regulation Of Histone Modification Mitotic Cell Cycle Cellular Response To Starvation Notch Signaling Pathway Negative Regulation Of Macromitophagy Positive Regulation Of Chaperone-mediated Protein Complex Assembly Oligodendrocyte Apoptotic Process Polyubiquitinated Misfolded Protein Transport Regulation Of Reactive Oxygen Species Metabolic Process Protein Import B Cell Activation Transcription, DNA-templated Negative Regulation Of Cell Growth Cellular Response To DNA Damage Stimulus
Tagcloud ?		critically defective deubiquitinase deubiquitinates deubiquitination enter example h2a h2b hela hox identifies laevis ligase mitosis mitotic modifications notably nucleosomal owing posterior predominately prefers prerequisite segregation slow ubiquitination ubp xenopus	21kd accumulating acts anticipated bcl6 box correlates cul1 inversely ligase microrna mir mirna normally oncogene oncogenic promotes proteosomal rescue restored skp1 subfamily suppress suppressor suppressors tumorigenesis tumorigenicity ubiquitination unifying
Tagcloud (Difference) ?		critically defective deubiquitinase deubiquitinates deubiquitination enter example h2a h2b hela hox identifies laevis mitosis mitotic modifications notably nucleosomal owing posterior predominately prefers prerequisite segregation slow ubp xenopus	21kd accumulating acts anticipated bcl6 box correlates cul1 inversely microrna mir mirna normally oncogene oncogenic promotes proteosomal rescue restored skp1 subfamily suppress suppressor suppressors tumorigenesis tumorigenicity unifying
Tagcloud (Intersection) ?		ligase ubiquitination