USP16 and TTK

Number of citations of the paper that reports this interaction (PubMedID 28380042)
85

Data Source:
BioGRID (enzymatic study)

		USP16	TTK
Description		ubiquitin specific peptidase 16	TTK protein kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Kinetochore Nucleus Cytoplasm Spindle Membrane
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Ribosomal Small Subunit Binding Ubiquitin Binding Metal Ion Binding Histone H2A Deubiquitinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Kinetochore Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis DNA Damage Response Regulation Of Gene Expression Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Positive Regulation Of Ribosome Biogenesis Mitotic Nuclear Division	Nuclear Division Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Cell Population Proliferation Female Meiosis Chromosome Segregation Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Kinetochore Protein Localization To Chromosome Positive Regulation Of SMAD Protein Signal Transduction Nuclear Chromosome Segregation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Protein Localization To Meiotic Spindle Midzone
Pathways		Ub-specific processing proteases
Drugs			Pyrazolanthrone Fostamatinib BOS172722
Diseases
GWAS			Daytime sleep phenotypes ( 27126917) Macular thickness ( 30535121)
Interacting Genes		23 interacting genes: CALM1 CDK1 DNM1L EXOSC10 FAU FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4C16 ISG15 LINC02381 PAX6 PLK1 PTOV1 SATB1 TTK UBC UBD XRN2 ZEB2	14 interacting genes: APP AZU1 CDCA8 CDK2 HSP90AA1 KNL1 MAPK6 POLR2A RAD52 RPS6KA1 TP53 TUBB TUBB1 USP16
Entrez ID		10600	7272
HPRD ID		06881	04973
Ensembl ID		ENSG00000156256	ENSG00000112742
Uniprot IDs		Q9Y5T5	P33981
PDB IDs		2I50 8WG5	2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G 4C4H 4C4I 4C4J 4CV8 4CV9 4CVA 4D2S 4H7X 4H7Y 4JS8 4JT3 4O6L 4ZEG 5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 5EH0 5EHL 5EHO 5EHY 5EI2 5EI6 5EI8 5LJJ 5MRB 5N7V 5N84 5N87 5N93 5N9S 5NA0 5NAD 5NTT 5O91 6B4W 6GVJ 6H3K 6N6O 6TN9 6TNB 6TNC 6TND 7CHM 7CHN 7CHT 7CIL 7CJA 7CLH 7LQD
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome Chromatin Remodeling Protein Tag Activity Chromosome Regulation Of Chromosome Organization Chromatin Organization Post-translational Protein Modification Protein Ubiquitination Protein Localization To Organelle Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Heterodimerization Activity Female Meiosis Chromosome Segregation Regulation Of Sister Chromatid Segregation Spindle Microtubule Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Segregation G2/M Transition Of Mitotic Cell Cycle Heterochromatin Formation Protein Localization To Chromatin Nucleoplasm Nucleus Mitotic Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Mitotic Nuclear Membrane Disassembly Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Telomerase RNA Localization To Cajal Body Protein Localization To Kinetochore Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Meiotic Chromosome Segregation Nuclear Membrane Disassembly Negative Regulation Of Biosynthetic Process Membrane Disassembly Negative Regulation Of Chromosome Organization CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Gene Expression Positive Regulation Of Protein Localization To Nucleus	Protein-containing Complex Regulation Of Chromosome Organization Regulation Of Cellular Component Organization Cellular Component Assembly Mitotic Cell Cycle Chromosome Organization Cell Division Nuclear Envelope Lumen Protein Tetramerization Regulation Of Mitotic Cell Cycle Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Spindle Assembly Intercellular Bridge Membraneless Organelle Assembly Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Heparan Sulfate Proteoglycan Binding Ubiquitin Protein Ligase Binding Response To Salt Stress Muscle Cell Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Molecular Function Activator Activity Disordered Domain Specific Binding Organelle Assembly Ephrin Receptor Binding Microglial Cell Activation Immune Effector Process Regulation Of Organelle Organization Positive Regulation Of Gene Expression Cytoplasm Spindle Organization Leukocyte Activation Involved In Inflammatory Response Nucleoplasm Protein-containing Complex Assembly Microtubule-based Process Response To Antibiotic Mitotic Sister Chromatid Segregation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nitric Oxide Biosynthetic Process Organelle Organization Sister Chromatid Segregation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Protein-containing Complex Organization
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