ELOVL5 and HTR4

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		ELOVL5	HTR4
Name		ELOVL fatty acid elongase 5	5-hydroxytryptamine receptor 4
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dendrite Cell Projection Neuronal Cell Body Dendritic Tree	Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Fatty Acid Elongase Activity Transferase Activity	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process	System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Mucus Secretion Large Intestinal Transit Regulation Of Postsynapse Assembly
Pathways		Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Serotonin receptors G alpha (s) signalling events
Drugs		alpha-Linolenic acid	Dihydroergotamine Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
GWAS		Cerebrospinal fluid AB1-42 levels ( 26252872 ) Daytime sleep phenotypes ( 27126917 ) Familial squamous cell lung carcinoma ( 29924316 ) Glaucoma ( 20363506 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Red cell distribution width ( 32888494 ) Survival in colorectal cancer (distant metastatic) ( 26586795 )	Airflow obstruction ( 22837378 ) Chronic obstructive pulmonary disease ( 30804561 28166215 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Diastolic blood pressure ( 30578418 ) FEV1 ( 30804560 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Lung function (FEV1) ( 28166213 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Lung function (FVC) ( 30804560 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011 ) Medication use (adrenergics, inhalants) ( 31015401 ) Mood instability ( 31168069 ) Peak expiratory flow ( 30804560 ) Periodontal microbiota ( 22699663 ) Pulmonary function ( 20010835 20010834 ) Pulmonary function (smoking interaction) ( 23284291 ) Systolic blood pressure ( 30578418 ) Urinary sodium excretion ( 31409800 )
Interacting Genes		14 interacting genes: GOSR2 HMOX1 HTR4 IGFBP5 NINJ2 PLP2 SLC39A9 STX7 SYNJ2BP SYS1 THSD7A TMEM243 TSNARE1 UBC	18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7
Entrez ID		60481	3360
HPRD ID		13268	09074
Ensembl ID		ENSG00000012660	ENSG00000164270
Uniprot IDs		A0A0A0MTI6 B3KWH9 Q9NYP7	A0A2D3FAF9 Q13639
PDB IDs		Not available	5EM9 7XT8 7XT9 7XTA
GO Terms Enriched among Interactors		SNARE Complex SNAP Receptor Activity SNARE Binding Membrane Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Regulation Of Endothelial Cell Proliferation Membrane Fusion Mitochondrial Outer Membrane Large Intestinal Transit Negative Regulation Of Skeletal Muscle Hypertrophy Negative Regulation Of Smooth Muscle Cell Proliferation Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Endomembrane System Vesicle Docking Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Vesicle Organization Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Insulin-like Growth Factor Binding Protein Complex Membrane Docking Tertiary Granule Establishment Of Protein Localization Regulation Of Epithelial Cell Proliferation Cellular Response To Cisplatin Negative Regulation Of Locomotion Insulin-like Growth Factor Ternary Complex Membrane Destabilizing Activity Positive Regulation Of Receptor Localization To Synapse	Membrane Endoplasmic Reticulum Membrane