ELOVL5

Name	ELOVL fatty acid elongase 5
Structure	No pdb structure
Interactors	14 interactors: GOSR2 HMOX1 HTR4 IGFBP5 NINJ2 PLP2 SLC39A9 STX7 SYNJ2BP SYS1 THSD7A TMEM243 TSNARE1 UBC
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dendrite Cell Projection Neuronal Cell Body Dendritic Tree
	Molecular Function	Protein Binding Fatty Acid Elongase Activity Transferase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process
Pathways	Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs	alpha-Linolenic acid
GWAS	Cerebrospinal fluid AB1-42 levels ( 26252872 ) Daytime sleep phenotypes ( 27126917 ) Familial squamous cell lung carcinoma ( 29924316 ) Glaucoma ( 20363506 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Red cell distribution width ( 32888494 ) Survival in colorectal cancer (distant metastatic) ( 26586795 )
Entrez ID	60481
HPRD ID	13268
Ensembl ID	ENSG00000012660
Uniprot IDs	A0A0A0MTI6 B3KWH9 Q9NYP7
PDB IDs	Not available
GO Terms Enriched among Interactors ?	SNARE Complex SNAP Receptor Activity SNARE Binding Membrane Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Regulation Of Endothelial Cell Proliferation Membrane Fusion Mitochondrial Outer Membrane Large Intestinal Transit Negative Regulation Of Skeletal Muscle Hypertrophy Negative Regulation Of Smooth Muscle Cell Proliferation Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Endomembrane System Vesicle Docking Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Vesicle Organization Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Insulin-like Growth Factor Binding Protein Complex Membrane Docking Tertiary Granule Establishment Of Protein Localization Regulation Of Epithelial Cell Proliferation Cellular Response To Cisplatin Negative Regulation Of Locomotion Insulin-like Growth Factor Ternary Complex Membrane Destabilizing Activity Positive Regulation Of Receptor Localization To Synapse