PLAU and PLG

Number of citations of the paper that reports this interaction (PMID 4226004)
42

Data Source:
HPRD (in vitro)

		PLAU	PLG
Gene Name		plasminogen activator, urokinase	plasminogen
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Protein Domain Specific Binding Apolipoprotein Binding
	Biological Process	Response To Hypoxia Proteolysis Chemotaxis Signal Transduction Blood Coagulation Regulation Of Receptor Activity Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Proliferation Fibrinolysis Regulation Of Wound Healing Regulation Of Smooth Muscle Cell-matrix Adhesion	Platelet Degranulation Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Tissue Regeneration Fibrinolysis Cellular Protein Metabolic Process Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Dissolution of Fibrin Clot	Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Dissolution of Fibrin Clot Platelet degranulation Degradation of the extracellular matrix Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Orphan transporters
Drugs		Urokinase Amiloride 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine 2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine CRA_10655 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine 2-Amino-5-Hydroxy-Benzimidazole N-(1-Adamantyl)-N\'-(4-Guanidinobenzyl)Urea 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N\'-Beta-Alanine 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE 6-FLUORO-2-(2-HYDROXY-3-ISOBUTOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine (2R)-1-(2,6-dimethylphenoxy)propan-2-amine 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide	Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic Acid Aminocaproic Acid Bicine Aprotinin
Diseases
GWAS			Aging ( 22773346) Lp (a) levels ( 21900290)
Protein-Protein Interactions		24 interactors: ALAS1 BTK CEBPG CTSB CTSL ELAVL1 F2 HGF IGF2R LRP2 MYC NID1 PDGFC PLAT PLAUR PLG SCAMP5 SERPINA5 SERPINB2 SERPINB6 SERPINE1 SERPINE2 SERPINF2 ST14	61 interactors: ACTB AMOT ANXA2 APOH ATP5B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 LAMA5 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1
Entrez ID		5328	5340
HPRD ID		01883	01417
Ensembl ID		ENSG00000122861	ENSG00000122194
Uniprot IDs		P00749 Q59GZ8	P00747 Q5TEH5
PDB IDs		1C5W 1C5X 1C5Y 1C5Z 1EJN 1F5K 1F5L 1F92 1FV9 1GI7 1GI8 1GI9 1GJ7 1GJ8 1GJ9 1GJA 1GJB 1GJC 1GJD 1KDU 1LMW 1O3P 1O5A 1O5B 1O5C 1OWD 1OWE 1OWH 1OWI 1OWJ 1OWK 1SC8 1SQA 1SQO 1SQT 1U6Q 1URK 1VJ9 1VJA 1W0Z 1W10 1W11 1W12 1W13 1W14 2FD6 2I9A 2I9B 2NWN 2O8T 2O8U 2O8W 2R2W 2VIN 2VIO 2VIP 2VIQ 2VIV 2VIW 2VNT 3BT1 3BT2 3IG6 3KGP 3KHV 3KID 3M61 3MHW 3MWI 3OX7 3OY5 3OY6 3PB1 3QN7 3U73 4DVA 4DW2 4FU7 4FU8 4FU9 4FUB 4FUC 4FUD 4FUE 4FUF 4FUG 4FUH 4FUI 4FUJ 4GLY 4JK5 4JK6	1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4DCB 4DUR 4DUU 5HPG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Fibrinolysis Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Body Fluid Levels Regulation Of Protein Processing Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Response To Wounding Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Plasminogen Activation Response To Stress Positive Regulation Of Blood Coagulation Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Coagulation Negative Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Wound Healing Secretion By Cell Platelet Degranulation Exocytosis Platelet Activation Extracellular Matrix Organization Extracellular Structure Organization Secretion Extracellular Matrix Disassembly Cell Activation Multicellular Organismal Development Developmental Process System Development Negative Regulation Of Catalytic Activity Anatomical Structure Development Response To Stimulus Positive Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway	Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Migration Regulation Of Endopeptidase Activity Regulation Of Cell Motility Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stress Regulation Of Fibrinolysis Platelet Activation Regulation Of Protein Processing Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Cell Activation Positive Regulation Of Coagulation Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Protein Processing Negative Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Defense Response Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Peptidase Activity Zymogen Activation Negative Regulation Of Hydrolase Activity
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed
Tagcloud (Intersection) ?