PLAU and PLAUR

Number of citations of the paper that reports this interaction (PMID 3031025)
78

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PLAU	PLAUR
Gene Name		plasminogen activator, urokinase	plasminogen activator, urokinase receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Extracellular Vesicular Exosome	Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome Invadopodium Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Receptor Activity Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity
	Biological Process	Response To Hypoxia Proteolysis Chemotaxis Signal Transduction Blood Coagulation Regulation Of Receptor Activity Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Proliferation Fibrinolysis Regulation Of Wound Healing Regulation Of Smooth Muscle Cell-matrix Adhesion	C-terminal Protein Lipidation Movement Of Cell Or Subcellular Component Chemotaxis Signal Transduction Blood Coagulation Attachment Of GPI Anchor To Protein Regulation Of Proteolysis Urokinase Plasminogen Activator Signaling Pathway Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Dissolution of Fibrin Clot	Post-translational protein modification Attachment of GPI anchor to uPAR Dissolution of Fibrin Clot Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Urokinase Amiloride 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine 2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine CRA_10655 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine 2-Amino-5-Hydroxy-Benzimidazole N-(1-Adamantyl)-N\'-(4-Guanidinobenzyl)Urea 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N\'-Beta-Alanine 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE 6-FLUORO-2-(2-HYDROXY-3-ISOBUTOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine (2R)-1-(2,6-dimethylphenoxy)propan-2-amine 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide	Alteplase Urokinase Reteplase Anistreplase Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ALAS1 BTK CEBPG CTSB CTSL ELAVL1 F2 HGF IGF2R LRP2 MYC NID1 PDGFC PLAT PLAUR PLG SCAMP5 SERPINA5 SERPINB2 SERPINB6 SERPINE1 SERPINE2 SERPINF2 ST14	20 interactors: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN
Entrez ID		5328	5329
HPRD ID		01883	01421
Ensembl ID		ENSG00000122861	ENSG00000011422
Uniprot IDs		P00749 Q59GZ8	M0R1I2 Q03405
PDB IDs		1C5W 1C5X 1C5Y 1C5Z 1EJN 1F5K 1F5L 1F92 1FV9 1GI7 1GI8 1GI9 1GJ7 1GJ8 1GJ9 1GJA 1GJB 1GJC 1GJD 1KDU 1LMW 1O3P 1O5A 1O5B 1O5C 1OWD 1OWE 1OWH 1OWI 1OWJ 1OWK 1SC8 1SQA 1SQO 1SQT 1U6Q 1URK 1VJ9 1VJA 1W0Z 1W10 1W11 1W12 1W13 1W14 2FD6 2I9A 2I9B 2NWN 2O8T 2O8U 2O8W 2R2W 2VIN 2VIO 2VIP 2VIQ 2VIV 2VIW 2VNT 3BT1 3BT2 3IG6 3KGP 3KHV 3KID 3M61 3MHW 3MWI 3OX7 3OY5 3OY6 3PB1 3QN7 3U73 4DVA 4DW2 4FU7 4FU8 4FU9 4FUB 4FUC 4FUD 4FUE 4FUF 4FUG 4FUH 4FUI 4FUJ 4GLY 4JK5 4JK6	1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Fibrinolysis Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Body Fluid Levels Regulation Of Protein Processing Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Response To Wounding Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Plasminogen Activation Response To Stress Positive Regulation Of Blood Coagulation Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Coagulation Negative Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Wound Healing Secretion By Cell Platelet Degranulation Exocytosis Platelet Activation Extracellular Matrix Organization Extracellular Structure Organization Secretion Extracellular Matrix Disassembly Cell Activation Multicellular Organismal Development Developmental Process System Development Negative Regulation Of Catalytic Activity Anatomical Structure Development Response To Stimulus Positive Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway	Cell Motility Cell Migration Locomotion Peptidyl-tyrosine Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Regulation Of Cell Proliferation Regulation Of Collagen Catabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Regulation Of Cell Migration Regulation Of Smooth Muscle Cell Migration Defense Response Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Developmental Process Endocytosis Regulation Of Apoptotic Process Negative Regulation Of Blood Coagulation Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Negative Regulation Of Coagulation Regulation Of Cell Death Blood Coagulation Hemostasis Protein Autophosphorylation Negative Regulation Of Wound Healing Cell Adhesion Leukocyte Migration Innate Immune Response Regulation Of Innate Immune Response Cell Adhesion Mediated By Integrin Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Blood Coagulation Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Vesicle-mediated Transport Activated T Cell Proliferation Integrin-mediated Signaling Pathway Regulation Of Wound Healing Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cellular Process Regulation Of Defense Response To Virus By Virus Positive Regulation Of Cell Adhesion Extracellular Matrix Organization
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa scgb1d2 scgb2a1 serpinb5 thbs1 thbs2	alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1
Tagcloud (Intersection) ?		serpine1