PLAU and ST14

Number of citations of the paper that reports this interaction (PMID 10962009)
71

Data Source:
HPRD (in vitro)

		PLAU	ST14
Gene Name		plasminogen activator, urokinase	suppression of tumorigenicity 14 (colon carcinoma)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Extracellular Vesicular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Response To Hypoxia Proteolysis Chemotaxis Signal Transduction Blood Coagulation Regulation Of Receptor Activity Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Proliferation Fibrinolysis Regulation Of Wound Healing Regulation Of Smooth Muscle Cell-matrix Adhesion	Proteolysis Keratinocyte Differentiation
Pathways		Dissolution of Fibrin Clot
Drugs		Urokinase Amiloride 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine 2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine CRA_10655 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine 2-Amino-5-Hydroxy-Benzimidazole N-(1-Adamantyl)-N\'-(4-Guanidinobenzyl)Urea 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N\'-Beta-Alanine 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE 6-FLUORO-2-(2-HYDROXY-3-ISOBUTOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine (2R)-1-(2,6-dimethylphenoxy)propan-2-amine 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide	Urokinase Benzamidine
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ALAS1 BTK CEBPG CTSB CTSL ELAVL1 F2 HGF IGF2R LRP2 MYC NID1 PDGFC PLAT PLAUR PLG SCAMP5 SERPINA5 SERPINB2 SERPINB6 SERPINE1 SERPINE2 SERPINF2 ST14	7 interactors: CDCP1 F2RL1 HGF PDGFC PLAU RGS16 SPINT1
Entrez ID		5328	6768
HPRD ID		01883	06005
Ensembl ID		ENSG00000122861	ENSG00000149418
Uniprot IDs		P00749 Q59GZ8	Q9Y5Y6
PDB IDs		1C5W 1C5X 1C5Y 1C5Z 1EJN 1F5K 1F5L 1F92 1FV9 1GI7 1GI8 1GI9 1GJ7 1GJ8 1GJ9 1GJA 1GJB 1GJC 1GJD 1KDU 1LMW 1O3P 1O5A 1O5B 1O5C 1OWD 1OWE 1OWH 1OWI 1OWJ 1OWK 1SC8 1SQA 1SQO 1SQT 1U6Q 1URK 1VJ9 1VJA 1W0Z 1W10 1W11 1W12 1W13 1W14 2FD6 2I9A 2I9B 2NWN 2O8T 2O8U 2O8W 2R2W 2VIN 2VIO 2VIP 2VIQ 2VIV 2VIW 2VNT 3BT1 3BT2 3IG6 3KGP 3KHV 3KID 3M61 3MHW 3MWI 3OX7 3OY5 3OY6 3PB1 3QN7 3U73 4DVA 4DW2 4FU7 4FU8 4FU9 4FUB 4FUC 4FUD 4FUE 4FUF 4FUG 4FUH 4FUI 4FUJ 4GLY 4JK5 4JK6	1EAW 1EAX 2FMV 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Fibrinolysis Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Body Fluid Levels Regulation Of Protein Processing Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Response To Wounding Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Plasminogen Activation Response To Stress Positive Regulation Of Blood Coagulation Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Coagulation Negative Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Wound Healing Secretion By Cell Platelet Degranulation Exocytosis Platelet Activation Extracellular Matrix Organization Extracellular Structure Organization Secretion Extracellular Matrix Disassembly Cell Activation Multicellular Organismal Development Developmental Process System Development Negative Regulation Of Catalytic Activity Anatomical Structure Development Response To Stimulus Positive Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway	Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Hemostasis Regulation Of Phosphatidylinositol 3-kinase Signaling Interleukin-10 Secretion Negative Regulation Of Chemokine Secretion Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Regulation Of Cell Motility Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Chemokine Secretion Chemokine (C-C Motif) Ligand 2 Secretion Positive Regulation Of Eosinophil Degranulation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Cell Migration Positive Regulation Of Phosphorylation Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Renin Secretion Into Blood Stream Myoblast Proliferation Interleukin-1 Beta Secretion Cell Motility Regulation Of Peptidyl-tyrosine Phosphorylation Interleukin-10 Production Regulation Of Catalytic Activity Positive Regulation Of Glomerular Filtration Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Cytokine Secretion Involved In Immune Response Mature Conventional Dendritic Cell Differentiation Interleukin-1 Secretion Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Interferon-gamma Secretion Negative Regulation Of Peptidase Activity Activation Of Protein Kinase Activity Positive Regulation Of Cell Projection Organization Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	acetylation box coding compartment downregulates emt enables epcam epithelial esrp1 expected h358 h3k27 h3k9 h4 hdac hgf immunocytochemistry immunoprecipitation mesenchymal metastasis migratory note protease rab25 serine splicing stroma zeb1
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	acetylation box coding compartment downregulates emt enables epcam epithelial esrp1 expected h358 h3k27 h3k9 h4 hdac hgf immunocytochemistry immunoprecipitation mesenchymal metastasis migratory note protease rab25 serine splicing stroma zeb1
Tagcloud (Intersection) ?