PLAU and NID1

Number of citations of the paper that reports this interaction (PMID 1499567)
4

Data Source:
HPRD (in vitro)

		PLAU	NID1
Gene Name		plasminogen activator, urokinase	nidogen 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Extracellular Vesicular Exosome	Extracellular Region Basement Membrane Basal Lamina Extracellular Matrix Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding
	Biological Process	Response To Hypoxia Proteolysis Chemotaxis Signal Transduction Blood Coagulation Regulation Of Receptor Activity Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Proliferation Fibrinolysis Regulation Of Wound Healing Regulation Of Smooth Muscle Cell-matrix Adhesion	Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Glomerular Basement Membrane Development Basement Membrane Organization
Pathways		Dissolution of Fibrin Clot	Laminin interactions Degradation of the extracellular matrix
Drugs		Urokinase Amiloride 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine 2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine CRA_10655 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine 2-Amino-5-Hydroxy-Benzimidazole N-(1-Adamantyl)-N\'-(4-Guanidinobenzyl)Urea 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N\'-Beta-Alanine 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE 6-FLUORO-2-(2-HYDROXY-3-ISOBUTOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine (2R)-1-(2,6-dimethylphenoxy)propan-2-amine 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
Diseases
GWAS			Cutaneous nevi ( 21478494)
Protein-Protein Interactions		24 interactors: ALAS1 BTK CEBPG CTSB CTSL ELAVL1 F2 HGF IGF2R LRP2 MYC NID1 PDGFC PLAT PLAUR PLG SCAMP5 SERPINA5 SERPINB2 SERPINB6 SERPINE1 SERPINE2 SERPINF2 ST14	21 interactors: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL
Entrez ID		5328	4811
HPRD ID		01883	00574
Ensembl ID		ENSG00000122861	ENSG00000116962
Uniprot IDs		P00749 Q59GZ8	P14543
PDB IDs		1C5W 1C5X 1C5Y 1C5Z 1EJN 1F5K 1F5L 1F92 1FV9 1GI7 1GI8 1GI9 1GJ7 1GJ8 1GJ9 1GJA 1GJB 1GJC 1GJD 1KDU 1LMW 1O3P 1O5A 1O5B 1O5C 1OWD 1OWE 1OWH 1OWI 1OWJ 1OWK 1SC8 1SQA 1SQO 1SQT 1U6Q 1URK 1VJ9 1VJA 1W0Z 1W10 1W11 1W12 1W13 1W14 2FD6 2I9A 2I9B 2NWN 2O8T 2O8U 2O8W 2R2W 2VIN 2VIO 2VIP 2VIQ 2VIV 2VIW 2VNT 3BT1 3BT2 3IG6 3KGP 3KHV 3KID 3M61 3MHW 3MWI 3OX7 3OY5 3OY6 3PB1 3QN7 3U73 4DVA 4DW2 4FU7 4FU8 4FU9 4FUB 4FUC 4FUD 4FUE 4FUF 4FUG 4FUH 4FUI 4FUJ 4GLY 4JK5 4JK6	1NDX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Fibrinolysis Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Body Fluid Levels Regulation Of Protein Processing Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Response To Wounding Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Plasminogen Activation Response To Stress Positive Regulation Of Blood Coagulation Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Coagulation Negative Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Wound Healing Secretion By Cell Platelet Degranulation Exocytosis Platelet Activation Extracellular Matrix Organization Extracellular Structure Organization Secretion Extracellular Matrix Disassembly Cell Activation Multicellular Organismal Development Developmental Process System Development Negative Regulation Of Catalytic Activity Anatomical Structure Development Response To Stimulus Positive Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Cell Adhesion Regulation Of Body Fluid Levels Cell-substrate Adhesion Blood Coagulation Hemostasis Blood Vessel Development Vasculature Development Cell-matrix Adhesion Platelet Degranulation Locomotion Wound Healing Chemotaxis Platelet Activation Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Blood Vessel Morphogenesis Response To Wounding Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Axonogenesis Platelet Aggregation Cardiovascular System Development Tissue Development Retinal Blood Vessel Morphogenesis Endochondral Ossification Axon Development Substrate Adhesion-dependent Cell Spreading Angiogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Response To External Stimulus Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell-substrate Junction Assembly Neuron Projection Morphogenesis Vesicle-mediated Transport Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Developmental Process Collagen Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Morphogenesis Involved In Differentiation Negative Regulation Of Lipoprotein Metabolic Process Multicellular Organismal Development
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	accordance biogenesis bound brains clip details enriched immunoprecipitation intron linking messenger mirna mirnas neurexin neurodegeneration neurodevelopmental neurological nrxn1 pirnas processed reexamine represses rnas seq srnas systematically tar tardbp tdp
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	accordance biogenesis bound brains clip details enriched immunoprecipitation intron linking messenger mirna mirnas neurexin neurodegeneration neurodevelopmental neurological nrxn1 pirnas processed reexamine represses rnas seq srnas systematically tar tardbp tdp
Tagcloud (Intersection) ?