PLAU and NID1

Number of citations of the paper that reports this interaction (PubMedID 1499567)
0

Data Source:
HPRD (in vitro)

		PLAU	NID1
Description		plasminogen activator, urokinase	nidogen 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Serine Protease Inhibitor Complex Protein Complex Involved In Cell-matrix Adhesion Serine-type Endopeptidase Complex	Extracellular Region Basement Membrane Extracellular Matrix Extracellular Exosome Cell Periphery Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Receptor Ligand Activity	Extracellular Matrix Structural Constituent Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding Extracellular Matrix Binding
	Biological Process	Response To Hypoxia Proteolysis Chemotaxis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Plasminogen Activation Negative Regulation Of Plasminogen Activation Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Plasminogen Activation Regulation Of Cell Adhesion Mediated By Integrin Urokinase Plasminogen Activator Signaling Pathway Regulation Of Cell Population Proliferation Fibrinolysis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Negative Regulation Of Fibrinolysis Regulation Of Wound Healing Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Integrin-mediated Signaling Pathway	Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Glomerular Basement Membrane Development Positive Regulation Of Cell Adhesion Positive Regulation Of Muscle Cell Differentiation Basement Membrane Organization Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Neutrophil degranulation Dissolution of Fibrin Clot	Degradation of the extracellular matrix Degradation of the extracellular matrix Laminin interactions Laminin interactions
Drugs		Amiloride 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine CRA_10655 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine 2-Amino-1H-benzimidazol-5-ol N-(1-adamantyl)-N'-(4-guanidinobenzyl)urea 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine Fibrinolysin 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine (2R)-1-(2,6-dimethylphenoxy)propan-2-amine 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide	Urokinase
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908)	Cutaneous nevi ( 21478494) Diverticulitis ( 28585551) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean platelet volume ( 32888494) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Urate levels in overweight individuals ( 25811787)
Interacting Genes		25 interacting genes: ADAM28 ALAS1 BTK CEBPG CTSB CTSL ELAVL1 F2 HGF IGF2R KAT8 LRP2 MYC NID1 PDGFC PLAT PLAUR PLG SCAMP5 SERPINA5 SERPINB2 SERPINB6 SERPINE1 SERPINF2 ST14	21 interacting genes: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL
Entrez ID		5328	4811
HPRD ID		01883	00574
Ensembl ID		ENSG00000122861	ENSG00000116962
Uniprot IDs		B4DNJ4 E7ET40 P00749 Q59GZ8	P14543
PDB IDs		1C5W 1C5X 1C5Y 1C5Z 1EJN 1F5K 1F5L 1F92 1FV9 1GI7 1GI8 1GI9 1GJ7 1GJ8 1GJ9 1GJA 1GJB 1GJC 1GJD 1KDU 1LMW 1O3P 1O5A 1O5B 1O5C 1OWD 1OWE 1OWH 1OWI 1OWJ 1OWK 1SC8 1SQA 1SQO 1SQT 1U6Q 1URK 1VJ9 1VJA 1W0Z 1W10 1W11 1W12 1W13 1W14 2FD6 2I9A 2I9B 2NWN 2O8T 2O8U 2O8W 2R2W 2VIN 2VIO 2VIP 2VIQ 2VIV 2VIW 2VNT 3BT1 3BT2 3IG6 3KGP 3KHV 3KID 3M61 3MHW 3MWI 3OX7 3OY5 3OY6 3PB1 3QN7 3U73 4DVA 4DW2 4FU7 4FU8 4FU9 4FUB 4FUC 4FUD 4FUE 4FUF 4FUG 4FUH 4FUI 4FUJ 4GLY 4H42 4JK5 4JK6 4K24 4MNV 4MNW 4MNX 4MNY 4OS1 4OS2 4OS4 4OS5 4OS6 4OS7 4X0W 4X1N 4X1P 4X1Q 4X1R 4X1S 4XSK 4ZHL 4ZHM 4ZKN 4ZKO 4ZKR 4ZKS 5HGG 5WXF 5WXO 5WXP 5WXQ 5WXR 5WXS 5WXT 5XG4 5YC6 5YC7 5Z1C 5ZA7 5ZA8 5ZA9 5ZAE 5ZAF 5ZAG 5ZAH 5ZAJ 5ZC5 6AG2 6AG3 6AG7 6AG9 6JYP 6JYQ 6L04 6L05 6NMB 6XVD 7DZD 7VM4 7VM5 7VM6 7VM7 7ZRR 7ZRT
Enriched GO Terms of Interacting Partners?		Regulation Of Fibrinolysis Fibrinolysis Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Extracellular Matrix Extracellular Space Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Extracellular Region Regulation Of Response To Wounding Regulation Of Plasminogen Activation Serine Protease Inhibitor Complex Positive Regulation Of Wound Healing Regulation Of Multicellular Organismal Process Negative Regulation Of Plasminogen Activation Regulation Of Body Fluid Levels Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Multicellular Organismal Process Protease Binding Peptidase Inhibitor Activity External Side Of Plasma Membrane Proteoglycan Binding Regulation Of Protein Processing Regulation Of Cytokine Production Regulation Of Protein Maturation Extracellular Exosome Platelet Alpha Granule Lumen Serine-type Endopeptidase Activity Negative Regulation Of Gene Expression Peptidase Activity Negative Regulation Of Protein Processing Developmental Process Negative Regulation Of Protein Maturation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Cytokine Production Endopeptidase Activity Peptidase Inhibitor Complex Trans-synaptic Signaling By BDNF Blood Coagulation Coagulation Hemostasis Endolysosome Lumen Signaling Receptor Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Basement Membrane Extracellular Space Blood Coagulation, Fibrin Clot Formation Regulation Of Cell Adhesion Cell Adhesion Regulation Of Cell-substrate Adhesion Protein Activation Cascade Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Protein Complex Involved In Cell-matrix Adhesion Cell-matrix Adhesion Plasminogen Activation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Integrin Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Extracellular Exosome Endoplasmic Reticulum Lumen Heparin Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin Alphav-beta3 Complex Platelet Alpha Granule Fibrinolysis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Integrin-mediated Signaling Pathway External Side Of Plasma Membrane Positive Regulation Of Cell Migration Extracellular Vesicle Positive Regulation Of Cell Motility Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Laminin-1 Complex Cell Adhesion Molecule Binding Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Fibronectin Binding Extracellular Matrix Binding Blood Coagulation Coagulation Alphav-beta3 Integrin-IGF-1-IGF1R Complex Hemostasis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Cell Migration Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength
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