RFX3 and RFX4

Number of citations of the paper that reports this interaction (PMID 11682486)
11

Data Source:
HPRD (in vitro, in vivo)

		RFX3	RFX4
Gene Name		regulatory factor X, 3 (influences HLA class II expression)	regulatory factor X, 4 (influences HLA class II expression)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Type B Pancreatic Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Endocrine Pancreas Development Cilium Assembly Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Regulation Of Insulin Secretion Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Dorsal Spinal Cord Development Telencephalon Development Cerebellar Cortex Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Midbrain Development Cilium Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Processing
Pathways
Drugs
Diseases
GWAS			Cognitive test performance ( 17903297) Heart rate ( 23583979)
Protein-Protein Interactions		12 interactors: BIN1 CREB1 EWSR1 FHL2 FHL3 IRF6 PKNOX1 RFX1 RFX4 RFX6 TRAF2 TRIP6	3 interactors: ESR1 RFX2 RFX3
Entrez ID		5991	5992
HPRD ID		03215	04905
Ensembl ID		ENSG00000080298	ENSG00000111783
Uniprot IDs		P48380	Q33E94
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Gene Expression Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Organ Development System Development I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pancreatic D Cell Differentiation Pancreatic Epsilon Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Toll-like Receptor 4 Signaling Pathway Lipid Tube Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Localization Toll-like Receptor Signaling Pathway Atrial Cardiac Muscle Cell Development Developmental Process Muscle Structure Development Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Response To Inorganic Substance Epithelial Cell Differentiation Activation Of Innate Immune Response	Epithelial Cell Development Type B Pancreatic Cell Maturation Prostate Epithelial Cord Elongation Cilium-dependent Cell Motility Regulation Of Transcription From RNA Polymerase II Promoter Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Glandular Epithelial Cell Maturation Transcription, DNA-templated Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy RNA Biosynthetic Process Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cilium Or Flagellum-dependent Cell Motility Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Epithelial Cell Differentiation Regulation Of Type B Pancreatic Cell Development Vagina Development Uterus Development Type B Pancreatic Cell Development Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Prostate Gland Growth Cellular Response To Estradiol Stimulus Epithelial Cell Maturation Branching Involved In Prostate Gland Morphogenesis RNA Metabolic Process Mammary Gland Epithelial Cell Proliferation Epithelial Cilium Movement Type B Pancreatic Cell Differentiation Female Genitalia Development Enteroendocrine Cell Differentiation Positive Regulation Of Monooxygenase Activity Branch Elongation Of An Epithelium Gene Expression Cellular Response To Estrogen Stimulus Glandular Epithelial Cell Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Axis Elongation Androgen Metabolic Process Prostate Gland Epithelium Morphogenesis Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Prostate Gland Morphogenesis Positive Regulation Of Nitric Oxide Biosynthetic Process
Tagcloud ?		1b bipolar brains butyrate deacetylases division exert f1bgfp facilitates fgf fgf1 fibroblast gfp glycogen gsk hdac lithium mood neurogenesis neuroprotective nspcs recapitulate rfx2 sirnas stabilizing trichostatin valproic vpa
Tagcloud (Difference) ?		1b bipolar brains butyrate deacetylases division exert f1bgfp facilitates fgf fgf1 fibroblast gfp glycogen gsk hdac lithium mood neurogenesis neuroprotective nspcs recapitulate rfx2 sirnas stabilizing trichostatin valproic vpa
Tagcloud (Intersection) ?