CAPRIN1 and RAG2

Data Source: HiPPIP (Novel)

		CAPRIN1	RAG2
Name		cell cycle associated protein 1	recombination activating 2
Structure
GO Annotations	Cellular Component	P-body Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Lamellipodium Dendrite Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Cell Projection Intracellular Membraneless Organelle Synapse	Nucleus Nucleoplasm DNA Recombinase Complex
	Molecular Function	Nucleotide Binding RNA Binding MRNA Binding Protein Binding ATP Binding Signaling Adaptor Activity Molecular Function Activator Activity Molecular Condensate Scaffold Activity	DNA Binding Chromatin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Sequence-specific DNA Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate Binding Histone H3K4me3 Reader Activity
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Nervous System Development Synapse Assembly Intracellular MRNA Localization Negative Regulation Of Translation Cell Differentiation Stress Granule Assembly Negative Regulation Of Translational Initiation Generation Of Neurons Positive Regulation Of Dendrite Morphogenesis Synapse Organization Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Stress Granule Assembly Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Membraneless Organelle Assembly	Mature B Cell Differentiation Involved In Immune Response B Cell Lineage Commitment Pre-B Cell Allelic Exclusion B Cell Homeostatic Proliferation T Cell Lineage Commitment DNA Recombination Chromatin Organization B Cell Differentiation T Cell Differentiation T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation In Thymus V(D)J Recombination Organ Growth Defense Response To Bacterium Positive Regulation Of Organ Growth DN2 Thymocyte Differentiation
Pathways		None	Interleukin-7 signaling MAPK6/MAPK4 signaling
Diseases		None	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232 ) Major depressive disorder x sex interaction ( 34099189 ) Systolic blood pressure ( 30224653 )	Rheumatoid arthritis ( 24390342 )
Novel Interactors		3 novel interactors: RAG1 RAG2 WT1	3 novel interactors: CAPRIN1 LMO2 RCN1
Interacting Genes		10 interacting genes: APP CEBPA DAPK1 EIF2AK2 FXR2 MFHAS1 PIN1 PKNOX1 PRMT1 WBP4	4 interacting genes: FOXP1 IPO5 RAG1 SKP2
Entrez ID		4076	5897
HPRD ID		03108	08913
Ensembl ID		ENSG00000135387	ENSG00000175097
Uniprot IDs		Q14444	P55895
PDB IDs		4WBE 4WBP 6TA7 7XHG 8TH7	8T4R
GO Terms Enriched among Interactors		Regulation Of Translation DNA Recombinase Complex Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Pre-B Cell Allelic Exclusion Negative Regulation Of Translation Sequence-specific DNA Binding Positive Regulation Of Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Metabolic Process Nucleus Regulation Of Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade Regulation Of Hematopoietic Stem Cell Proliferation Mononuclear Cell Differentiation Negative Regulation Of Gene Expression V(D)J Recombination Regulation Of Developmental Process Identical Protein Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Leukocyte Differentiation Positive Regulation Of P38MAPK Cascade T Cell Differentiation Regulation Of Protein Localization To Nucleus Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Metabolic Process Chromatin Organization Defense Response Regulation Of Cell Development Regulation Of Hemopoiesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of Multicellular Organismal Development Chromatin Binding Cellular Developmental Process Macromolecule Metabolic Process	Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Lymphocyte Apoptotic Process Double-stranded DNA Endonuclease Activity Negative Regulation Of Leukocyte Apoptotic Process DNA Recombinase Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Interleukin-21 Production