IPO13 and EIF1AX

Number of citations of the paper that reports this interaction (PubMedID 11447110)
63

Data Source:
HPRD (in vitro)

		IPO13	EIF1AX
Description		importin 13	eukaryotic translation initiation factor 1A X-linked
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Synapse
	Molecular Function	Protein Binding Small GTPase Binding	TRNA Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport	Translation Translational Initiation Ribosome Assembly
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		20 interacting genes: ALX1 ARX CRX EIF1AX GK HMBOX1 MAGOH NOSIP NPSR1 NUP50 PAX3 PAX6 PBX4 PITX1 PSMA1 RAN RBM8A RNF10 RPL5 UBE2I	9 interacting genes: APP EIF2S1 EIF3C EIF5 EIF5B HSPB1 IKBKG IPO13 RFPL3
Entrez ID		9670	1964
HPRD ID		13742	02174
Ensembl ID		ENSG00000117408	ENSG00000173674
Uniprot IDs		O94829	P47813
PDB IDs		2X19 2XWU 3ZJY	1D7Q 3ZJY 4KZY 4KZZ 6YBW 6ZMW 6ZP4 7A09 7QP6 7QP7 7SYQ 7SYR 7SYS 7SYV 7SYW 7SYX 7TQL 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL
Enriched GO Terms of Interacting Partners?		Translation Initiation Factor Activity Chromatin Translational Initiation Exon-exon Junction Subcomplex Mago-y14 Cytosol Sequence-specific Double-stranded DNA Binding Nuclear Export Nuclear Transport Nucleocytoplasmic Transport RNA Transport RNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Neuron Development Translation Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex RNA Export From Nucleus Nuclear Pore Nucleobase-containing Compound Transport Translation Factor Activity, RNA Binding Exon-exon Junction Complex Cell Development Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Pronuclear Fusion Regulation Of Macromolecule Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Chromatin Binding Cytoplasm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process MRNA Transport Sequence-specific DNA Binding Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development SUMO Conjugating Enzyme Activity Structural Constituent Of Presynapse Cytoplasmic Translational Initiation	Translation Initiation Factor Activity Regulation Of Translation Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Translational Initiation Regulation Of Protein Metabolic Process Cellular Response To Manganese Ion Response To Manganese Ion Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 48S Preinitiation Complex Ribosome Assembly Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Gene Expression Protein-containing Complex Assembly Regulation Of Macromolecule Biosynthetic Process Cytoplasm Membraneless Organelle Assembly Protein-containing Complex Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Cellular Component Assembly Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Translation Initiation Ternary Complex RNA Binding Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Interleukin-1 Production Regulation Of Macromolecule Metabolic Process Ribosome Binding Axo-dendritic Transport Regulation Of Apoptotic Signaling Pathway Synapse Response To Heat Acetylcholine Receptor Activator Activity Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Metabolic Process
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