IPO13 and GK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IPO13	GK
Description		importin 13	glycerol kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding	Nucleotide Binding Glycerol Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Metal Ion Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport	Carbohydrate Metabolic Process Glycerol Metabolic Process Glycerol-3-phosphate Metabolic Process Triglyceride Metabolic Process Triglyceride Biosynthetic Process Glycerol Catabolic Process Glycerol-3-phosphate Biosynthetic Process
Pathways			Triglyceride biosynthesis
Drugs
Diseases			Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Cardiovascular risk factors (age interaction) ( 20838585)
Interacting Genes		20 interacting genes: ALX1 ARX CRX EIF1AX GK HMBOX1 MAGOH NOSIP NPSR1 NUP50 PAX3 PAX6 PBX4 PITX1 PSMA1 RAN RBM8A RNF10 RPL5 UBE2I	11 interacting genes: AOX1 APCS CLPTM1L CYP3A4 EIF4G1 FBXO28 GPD1 IPO13 NR4A1 OPLAH RXRA
Entrez ID		9670	2710
HPRD ID		13742	08363
Ensembl ID		ENSG00000117408	ENSG00000198814
Uniprot IDs		O94829	A0A8I5KXY7 B4DH54 P32189
PDB IDs		2X19 2XWU 3ZJY
Enriched GO Terms of Interacting Partners?		Translation Initiation Factor Activity Chromatin Translational Initiation Exon-exon Junction Subcomplex Mago-y14 Cytosol Sequence-specific Double-stranded DNA Binding Nuclear Export Nuclear Transport Nucleocytoplasmic Transport RNA Transport RNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Neuron Development Translation Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex RNA Export From Nucleus Nuclear Pore Nucleobase-containing Compound Transport Translation Factor Activity, RNA Binding Exon-exon Junction Complex Cell Development Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Pronuclear Fusion Regulation Of Macromolecule Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Chromatin Binding Cytoplasm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process MRNA Transport Sequence-specific DNA Binding Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development SUMO Conjugating Enzyme Activity Structural Constituent Of Presynapse Cytoplasmic Translational Initiation	Aldehyde Oxidase Activity Identical Protein Binding NAD Binding Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Quinine 3-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Vitamin D 24-hydroxylase Activity Anandamide 11,12 Epoxidase Activity 1,8-cineole 2-exo-monooxygenase Activity Anandamide 14,15 Epoxidase Activity Vitamin D3 25-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle Nuclear Receptor Activity 5-oxoprolinase (ATP-hydrolyzing) Activity Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Alkaloid Catabolic Process Vitamin D Response Element Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Molybdopterin Cofactor Binding Xenobiotic Metabolic Process Iron Ion Binding Negative Regulation Of Monocyte Differentiation Testosterone 6-beta-hydroxylase Activity Vitamin D3 Metabolic Process Monoterpenoid Metabolic Process Lipid Hydroxylation Caffeine Oxidase Activity Cap-dependent Translational Initiation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Glycerol-3-phosphate Metabolic Process Non-canonical Inflammasome Complex Assembly Double-stranded DNA Binding Import Into Nucleus Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Protein Import Into Nucleus Positive Regulation Of Lipoprotein Transport Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway DNA Binding Domain Binding Oxidoreductase Activity Estrogen 16-alpha-hydroxylase Activity Positive Regulation Of Translation In Response To Stress
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