IPO13 and ARX

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		IPO13	ARX
Description		importin 13	aristaless related homeobox
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromatin Nucleus
	Molecular Function	Protein Binding Small GTPase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axon Guidance Positive Regulation Of Gene Expression Globus Pallidus Development Olfactory Bulb Development Cerebral Cortex Tangential Migration Embryonic Olfactory Bulb Interneuron Precursor Migration Cell Proliferation In Forebrain Cerebral Cortex GABAergic Interneuron Migration Cell Differentiation Forebrain Development Organ Growth Lipid Digestion Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Neuron Fate Commitment Neuron Development Regulation Of Epithelial Cell Proliferation Epithelial Cell Fate Commitment Interneuron Migration
Pathways
Drugs
Diseases			Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Early infantile epileptic encephalopathy; Ohtahara syndrome Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		20 interacting genes: ALX1 ARX CRX EIF1AX GK HMBOX1 MAGOH NOSIP NPSR1 NUP50 PAX3 PAX6 PBX4 PITX1 PSMA1 RAN RBM8A RNF10 RPL5 UBE2I	8 interacting genes: ACTN2 CYTIP DNM2 IPO13 NELL2 PKM SETD2 TLE5
Entrez ID		9670	170302
HPRD ID		13742	02307
Ensembl ID		ENSG00000117408	ENSG00000004848
Uniprot IDs		O94829	Q96QS3
PDB IDs		2X19 2XWU 3ZJY
Enriched GO Terms of Interacting Partners?		Translation Initiation Factor Activity Chromatin Translational Initiation Exon-exon Junction Subcomplex Mago-y14 Cytosol Sequence-specific Double-stranded DNA Binding Nuclear Export Nuclear Transport Nucleocytoplasmic Transport RNA Transport RNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Neuron Development Translation Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex RNA Export From Nucleus Nuclear Pore Nucleobase-containing Compound Transport Translation Factor Activity, RNA Binding Exon-exon Junction Complex Cell Development Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Pronuclear Fusion Regulation Of Macromolecule Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Chromatin Binding Cytoplasm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process MRNA Transport Sequence-specific DNA Binding Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development SUMO Conjugating Enzyme Activity Structural Constituent Of Presynapse Cytoplasmic Translational Initiation
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